S185
Clinical - Biomarkers of clinical response
ESTRO 2026
Neoadjuvant chemotherapy and radiotherapy were completed as planned in the totality of patients. After a median follow-up time of 42 months, the pCR rate was 31%. Patients were divided into two groups: pCR and not-pCR. Both groups were similar in terms of baseline patient characteristics, stage and laboratory parameters before treatment. There was no significant difference between the pCR and non-pCR groups other than MLR-1. The median MLR-1 level was 0.29 (Range: 0.1-1.8) in the pCR group and 0.34 (0.1-1.05) in the non-pCR group (p = 0.03). The median DFS and OS were 85 (range: 5-100) and 94 months (range: 7-102), respectively. The 5-year DFS and OS 62% and 79%, respectively. In table I, there are reported the results of univariate and multivariate analyses for OS and DFS. The following features demonstrated a statistically significant association with the outcomes: age, gender and PLR-2 with regard to OS; while pCR, SII-1 and PLR-2 for DFS (Table II). At multivariate analysis, the variables independently predictive of OS were: MLR-2 (p=0.04) and SIRI-2 (p=0.005), while the co-dependent variables were: Age&SII-2 (p=0.02) and MLR-2&PLR-2 (p=0.04).The only variable independently predictive of DFS was: pCR (p=0.04).
covariates. Conclusion: In this multicentre real-world cohort, females exhibited higher rates of AbE (AR/AC) under RT-ICI, while survival was overall similar between sexes. A longer ICI-to-RT interval and lower BMI favoured survival in both sexes, and elevated CRP was prognostic in males only. These signals support incorporating sex-aware stratification and timing considerations into future RT-ICI trial design and clinical decision-making. Keywords: sex-based differences, abscopal effects, RT-ICI Inflammatory markers for response prediction in locally advanced rectal cancer: a single-center study Marco Lucarelli 1 , Giulia de Pasquale 2 , Monica Di Tommaso 3 , Consuelo Rosa 3 , Andrea D'Aviero 3,2 , Domenico Genovesi 2,3 1 . Department of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy. 2 Department of Medical, Oral and Biotechnological Sciences, "Gabriele D'Annunzio" Università di Chieti, Chieti, Italy. 3 Department of Radiation Oncology, "S.S. Annunziata", Chieti Hospital, Chieti, Italy Purpose/Objective: The aim of this study was to evaluate the efficacy of inflammatory markers to predict the likelihood of response and prognosis in patients with locally advanced rectal cancer (LARC) treated with dose- intensification long-course neoadjuvant chemoradiotherapy (nCRT). Material/Methods: A retrospective analysis was conducted, including patients with LARC who received nCRT at the Department of Radiation Oncology of Chieti followed by surgery from March 2015 to March 2024. Inflammatory ratios were calculated from pre-nCRT and post-nCRT blood samples. The analyzed ratios were: NLR, PLR, MLR, SII (platelet count × neutrophil count/lymphocyte count) and SIRI (neutrophil count × monocyte count/lymphocyte count). The ratios Digital Poster 1889 calculated in the pre-CRT time were named as NLR-1, PLR-1, MLR-1, SII-1 and SIRI-1; while those calculated in the post-nCRT time were named as NLR-2, PLR-2, LMR- 2, SII-2 and SIRI-2. The study endpoints were locoregional control (LC), overall survival (OS), disease- free survival (DFS), and pathological complete response (pCR) rate. Results: In the study, 122 patients with LARC, who had undergone nCRT treatment were evaluated.
Conclusion: Our study findings suggest that inflammatory markers and particularly their combinations could potentially contribute to predicting response and prognosis in LARC patients. Keywords: Rectum, Inflammation, Outcomes
Mini-Oral 1904
ST2 as a biomarker of late cardiotoxicity after adjuvant breast cancer radiotherapy: a six-year prospective follow-up study Mikko Moisander 1,2 , Hanna Aula 1,2 , Suvi Tuohinen 3,4 , Mari Hämäläinen 5 , Eeva Moilanen 5 , Heini Huhtala 6 , Kjell Nikus 2,3 , Vesa Virtanen 3 , Pirkko-Liisa Kellokumpu- Lehtinen 2,7 , Pekka Raatikainen 4 , Tanja Skyttä 1,2
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