S201
Clinical - Breast
ESTRO 2026
(%)Permanent Implant30 (63.8)Tissue Expander17 (36.2)Chemotherapyn (%)Neoadjuvant33 (70.2)Adjuvant11 (23.4)Implant Volume (cc)Median325Range100-590 Conclusion: To our knowledge, this is the first trial to demonstrate that higher RT doses to the posterior edge of the implant are significantly associated with capsular contracture development. These findings warrant validation in larger patient cohorts. Keywords: Radiotherapy, Prosthesis, Contracture Cosmetic and Functional Outcomes After Immediate One-Stage Direct-To-Implant Reconstruction and Post-Mastectomy Radiotherapy Ting Chun Lin 1 , Tsung-Chun Huang 2 , Ya-Yun Yu 1 , Chi- Hsien Huang 1 , Yu-Rou Chiou 1 , Ji-An Liang 1 1 Department of Radiation Oncology, China Medical University Hospital, Taichung City, Taiwan. 2 Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung City, Taiwan Digital Poster 98
Digital Poster 96
Capsular contracture rates and associated risk factors after radiotherapy in reconstructed breasts Solin Onder 1 , Barbaros Aydin 1 , Ali İ brahim Sevinc 2 , Isil Basara Akin 3 , İ lknur Gorken 1 1 Radiation Oncology, Dokuz Eylul University, Izmir, Turkey. 2 General Surgery, Dokuz Eylul University, Izmir, Turkey. 3 Radiology, Dokuz Eylul University, Izmir, Turkey Purpose/Objective: Capsular contracture (CC) following radiotherapy (RT) in breast cancer patients with implant-based reconstruction (IBR) can lead to significant cosmetic complications and negatively impact quality of life. This study aimed to evaluate the incidence of CC observed in our center and investigate potential associated risk factors. Material/Methods: We retrospectively reviewed data from all IBR patients who received RT between 2014 and 2025. Categorical variables were analyzed using the Chi-square test. Continuous variables were assessed using the Mann- Whitney U test due to non-normal distribution (Shapiro-Wilk test). ROC analysis was performed for significant variables to determine optimal cutoff values. Results: A total of 47 implants from 45 patients were evaluated. Patient and tumor characteristics are summarized in Table 1. Median follow-up after RT was 41 months (range: 5–95). CC was observed in 8 patients (17%), with 62% classified as Baker grade 4. All cases occurred within the first 18 months post-RT. No statistically significant association was found between CC and implant location (p=0.706), nipple-sparing surgery (p=0.679), smoking history (p=0.801), comorbidities (p=0.169), chemotherapy (p=0.378), implant type (p=0.615), or cancer stage (p=0.625). However, the mean dose to the posterior edge of the implant (p=0.03) and the D2% dose (p=0.041) were significantly associated with CC. ROC analysis identified 5025 cGy as the optimal cutoff for mean posterior dose (AUC = 0.824, sensitivity 75%, specificity 94.9%) and 5262 cGy for D2% dose (AUC = 0.731, sensitivity 62.5%, specificity 79.5%).Table 1: Patient and tumor characteristicsAgeMedian42 (Range: 26– 57)T Stagen (%)T1a1 (2.1)T1b4 (8.5)T1c10 (21.3)T223 (48.9)T38 (17)T41 (2.1)N Stagen (%)N013 (27.7)N122 (46.8)N211 (23.4)N31 (2.1)Histological Subtypen (%)Invasive Ductal Carcinoma (IDC)21 (44.7)Invasive Lobular Carcinoma (ILC)8 (17)Others18 (38.3)Molecular Subtypen (%)Luminal A16 (34)Luminal B15 (31.9)Luminal B/HER2-positive5 (10.6)HER2-positive6 (12.8)Triple-negative5 (10.6)Implant Typen
Purpose/Objective: Post-mastectomy radiotherapy (PMRT) after
reconstructive surgery presents several challenges, including increased risks of capsular contracture, fibrosis, rippling, and aesthetic compromise. This study aims to evaluate the impact of radiation dose and field on the cosmetic and functional outcomes evaluated by plastic surgeons in breast cancer patients undergoing one-stage direct-to-implant reconstruction
followed by PMRT. Material/Methods: We prospectively collected the cosmesis and
functional outcome of breast cancer patients who underwent one-stage direct-to-implant reconstruction followed by PMRT between 2020 to 2024. Data collected included patients’ age, cancer stage, implant type and size, RT dose and RT field. Cosmetic and functional outcomes assessed included severity of capsular contracture (Baker grades I to IV), breast animation deformity (BAD; mild, moderate or severe), presence of rippling (yes or no), and cleavage formation (yes or no), each assessed by a plastic surgeon during the follow-up clinic visit. Correlation analysis between radiation parameters and the cosmetic outcomes was performed. Statistical analyses were conducted with R software (version 4.4.3). Results: Eighteen women were included in the analyses (Table 1). The mean age was 44.1 ± 8.3 years old (range: 35 to
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