S247
Clinical - Breast
ESTRO 2026
At univariate analysis, larger CTV volume and higher BMI were associated with grade 2 ASR (Figure 1), while in multivariate analysis, only CTV remained independently significant (odds ratio per 100 cc = 1.16, 95% CI 1.03–1.30, p = 0.013).
Conclusion: Our findings are consistent with previously published FAST-Forward experiences [2-3], confirming the feasibility and acceptable rates of acute skin reactions even when a SIB is delivered. Larger CTV volumes were associated with increased odds of grade 2 ASR, likely reflecting greater skin dose exposure. These results support the robustness of our dataset and highlight the importance of dosimetric parameters as potential predictors of ASR in patients treated with the FAST- Forward protocol, particularly in the context of SIB delivery. References: [1] Brunt AM, Cafferty FH, Wheatley D, et al.. Radiother Oncol. 2025;207:110915. doi:10.1016/j.radonc.2025.110915[2] Brunt AM, Wheatley D, Yarnold J, et al.. Radiother Oncol. 2016;120(1):114-118. doi:10.1016/j.radonc.2016.02.027[3] Murray Brunt A, Haviland JS, Wheatley DA, et al.. Lancet. 2020;395(10237):1613-1626. doi:10.1016/S0140- 6736(20)30932-6 Keywords: Acute skin reactions, FAST-Forward
Made with FlippingBook - Share PDF online