S375
Clinical - CNS
ESTRO 2026
relationship between perceived stress, patient characteristics, physical activity, fatigue and sleep in GBM patients before the start of radiotherapy. Material/Methods: Forty-two GBM patients were enrolled in the prospective study “Effect of Stress and Exercise on the Outcome after Chemo-Radiation (ERROR; NCT05431348)”. Collected data include patient characteristics; age, gender, Karnofsky Performance Status (KPS) and Body-Mass-Index (BMI), continuous measures via Whithings smartwatch (e.g. HeartRate, StepCount, SleepScore), and patient-reported outcomes. Included questionnaires were the Questionnaire on Stress in Cancer Patients (QSC-R23), International Physical Activtity Questionaire (IPAQ-SF), and the Multidimensional Fatigue Inventory (MFI-20). Reported are median values (min-max). Spearman correlation (R) was used to evaluate the relationship between the variables; in addition, a multivariate linear regression was performed to predict baseline stress. A p-value <0.05 was assumed significant. Results: The included patients were predominantly male (64%), had a median age of 62 (23-79) years and were treated with standard of care treatment schedule (radiation combined with temozolomide). Before the start of chemoradiation most patients had a KPS ≥ 80 (93%). The patients had a median BMI of 26 (20-45), physical activity of 1200 (0-8835), Metabolic Equivalent of Task (MET)-minutes/week, stress score of 1.0 (0.2-2.8), and a fatigue score of 52 (28-76). The baseline smartwatch data showed a median HeartRate of 80 (62-101) bpm, SleepScore of 84 (54-94) and a StepCount of 3496 (462-12375) per day. At baseline, a significant correlation was observed between gender and HeartRate (R=-0.35, p=0.03), KPS and fatigue (R=-0.59, P<0.001), KPS and StepCount (R=0.38, P<0.01), stress and fatigue (R=0.50, P<0.01), physical activity and fatigue (IPAQ R= -0.42, P<0.01); StepCount and fatigue R=-0.39, P=0.02), see Figure and Table. On multivariate analysis using the variables age, KPS, StepCount and fatigue to predict baseline stress the model reached an R2 of 0.36, with only a significant contribution of baseline fatigue (P<0.001).
in LMD-positive cases versus 9.6 months in LMD- negative cases (p<0.05). Two-year survival rates were 41.5% in LMD-positive and 33.6% in LMD-negative patients. LMD was more frequently observed in temporal lobe and infratentorial tumors, and in those with oligodendroglial histology (p=0.00). Conclusion: LMD occurs infrequently compared to local recurrences in HGG. Temporal and infratentorial tumours, particularly with oligodendroglial histology, appear at greater risk. Although overall survival did not significantly differ between LMD(+) and LMD(–) groups, early identification of molecular or genetic markers predictive of leptomeningeal spread and cerebrospinal-fluid-targeted preventive strategies should be prioritised in future studies. Keywords: Oligodendroglioma, Prognostic factors Association Between Perceived Stress, Physical Activity, and Fatigue in Glioblastoma Patients: Results from a Prospective Study (NCT05431348) Catharina ML Zegers 1 , Merle Vrancken 1 , Ruud MA Houben 1 , Ann Hoeben 2 , Martinus PG Broen 3 , Monique HME Anten 3 , Kon-Siong Jie 4 , Franchette van den Berkmortel 5 , Tom Rozema 6 , Alida A Postma 7 , Linda Ackermans 8 , Inge Compter 1 , Danielle BP Eekers 1 1 Department of Radiation Oncology (Maastro), GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, Netherlands. 2 Department of Medical Oncology, GROW Research Institute for Oncology and Mini-Oral 2843 Reproduction, Maastricht University Medical Centre+, Maastricht, Netherlands. 3 Department of Neurology, Maastricht University Medical Centre+, Maastricht, Netherlands. 4 Department of Internal Medicine, Zuyderland Medical Center Sittard, Sittard-Geleen, Netherlands. 5 Department of Medical Oncology, Zuyderland Medical Center Sittard, Sittard-Geleen, Netherlands. 6 Department of Radiotherapy, Verbeeten Institute, Tilburg, Netherlands. 7 Department of Radiology and Nuclear Medicine, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Center, Maastricht,, Maastricht, Netherlands. 8 Department of Neurosurgery, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Center, Maastricht,, Maastricht, Netherlands Purpose/Objective: Glioblastoma (GBM) is an aggressive, incurable brain tumor. The disease and its treatment can cause significant psychological distress. Stress hormones promote cell survival, immune suppression, and may promote therapy resistance. This study evaluates the
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