S401
Clinical - Gynaecological
ESTRO 2026
remains a major cause of morbidity and mortality worldwide[1], making the early and accurate assessment of treatment response paramount for optimizing patient management. Owing to limited prospective data regarding the optimal use and prognostic thresholds of interim FDG-PET/CT in LACC [2,3], this study aimed to prospectively evaluate the prognostic significance of changes ( Δ ) in metabolic and volumetric parameters obtained from interim and post-treatment FDG-PET/CT scans in patients with LACC treated with concurrent chemoradiotherapy (CCRT) and
brachytherapy (BRT). Material/Methods:
Conclusion: Awareness and proactive management of radiation-induced gynecological toxicities are critical for maintaining quality of life and ensuring treatment continuity. This guideline provides structured recommendations to support clinicians in delivering comprehensive, patient-centered supportive care. Keywords: Radiation-Induced, Gynecological, Toxicities Digital Poster Highlight 334 Prognostic Value of Interim and Post- Treatment FDG-PET/CT Metabolic Parameters in Locally Advanced Cervical Cancer Feyza Ya ş ar Da ş gın 1 , Süheyla Aytaç Arslan 1,2 , İ pek Pınar Aral 1,2 , Gonca Altını ş ık İ nan 1,2 , Fatma Arzu Görtan 3 , Zuhal Kandemir 3 , Karabekir Ercan 4 , Yılmaz Tezcan 1,2 1 Radiation Oncology, Ankara Bilkent City Hospital, Ankara, Turkey. 2 Radiation Oncology, Ankara Yildirim Beyazit University, Ankara, Turkey. 3 Nuclear Medicine, Ankara Bilkent City Hospital, Ankara, Turkey. 4 Radiology, Ankara Bilkent City Hospital, Ankara, Turkey
A total of 42 patients with histologically confirmed LACC who underwent baseline (PET1), interim (PET2), and early post- treatment 3rd month(PET3) PET/CT were prospectively analyzed. Interim PET (PET2) was performed following external beam radiotherapy but prior to brachytherapy(Figure 1). Metabolic parameters, including SUVmax, SUVmean, MTV and TLG were measured. The percentage changes( Δ ) between PET1–PET2 and PET1–PET3 were calculated, and their associations with disease-free survival (DFS) and overall survival (OS) were assessed using ROC analysis and survival curves.
Results: The median follow-up duration was 17 months (range: 6–28 months). During this period, 10 patients (23.8%) experienced recurrence and only one patient (2.4%) died. The median overall survival (OS) and disease-
Purpose/Objective: Locally advanced cervical cancer (LACC)
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