S34
Brachytherapy - General brachytherapy
ESTRO 2026
2;69(18).McMahon SJ, Prise KM. A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate. Front Oncol. 2021 Jun 29;11:689112.Dasu A. & Toma-Dasu I. (2015). Will intrafraction repair have negative consequences on extreme hypofractionation in prostate radiation therapy? British Journal of Radiology, 88(1056):20150588.Tien, C.J. et al. (2023). Brachytherapy, 22(5):593-606 – Modeling intrafraction DNA repair in HDR prostate brachytherapyDale RG. Radiation repair models for clinical application. Br J Radiol. 2019 Jan;92(1093):20180070. Digital Poster 1407 Person-centred nursing care in the Brachytherapy department. - Karolinska University Hospital, Solna. Moa Larsson, Helaleh Mavarani Brachytherapy, Karolinska University Hospital, Stockholm, Sweden Purpose/Objective: In a review (4), the perioperative environment is described as demanding, complex, highly technical. Perioperative nurses work in challenging situations while adressing the unique needs of patients (5). A study showed that patients valued being recognized as whole individuals, for instance by being adressed by name (7) which was perceived as treatment with dignity and respect (6).The aim is to describe nursing care with a focus on person-centered care [PCC], provided in brachytherapy. Highlighting how systematic nursing interventions based on communication, continuity and multidiscipinary collaborations supports cancerpatients throughout their treatment process, contributing to safety and Nursing practice in brachytherapy is structured around PCC principles. Prior to treatment, patients recieve verbal and written information about preparations, procedure, possible side effects and self- care. This information is repeated at the time of treatment, when patients can ask questions. After treatment, nurses offer telephonesupport if needed. When language/functional barriers occur, interpreters are arranged to ensure individualized PCC communication tailored to the patients need. During treatment, two nurses collaborate: one provides direct patient care while the other operates the brachyterapy equipment. Interventions before and after treatment ensure holistic care adressing the patient’s physical, psycological and extential needs (1,2). Communication is emphasised as a foundation for trust and continuty. increased satisfaction Material/Methods:
Conclusion: Conventional instantaneous BED calculations overestimate biological effectiveness in HDR brachytherapy, particularly for large implants, low- activity sources, and extended delivery times. Temporal dose reconstruction coupled with multi- pathway repair kinetics modeling reveals clinically significant spatial BED variations that may impact treatment outcomes. This framework, first time available for clinical use in patients, enables treatment optimization through delivery sequence modification and provides more accurate biological dose assessment for outcomes correlation studies. Full code and test cases will be made available at presentation time. Keywords: spatially/temporally resolved repair, bio- modeling References: Gardner LL, Thompson SJ, O'Connor JD, McMahon SJ. Modelling radiobiology. Phys Med Biol. 2024 Sep
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