S430
Clinical - Gynaecological
ESTRO 2026
Poster Discussion 1648
or resolution. Analyses were performed using SPSS v29. Results: Of 132 patients, 114 were included based on full medical records, contributing 553 follow- ups over a median of 75 months (IQR 48– 112). Median follow-ups per patient were 5 (IQR 1–12). At the first presentation, CTCAE grades were: Grade 1 (7.9%), Grade 2 (70.2%), Grade 3 (21.1%), and Grade 4 (0.9%). Over time, 16.7% experienced grade progression, 26.3% had persistent grade, and 57.0% achieved symptom resolution. Death due to CHC complications occurred in 7% of patients who presented with CHC. (Figure 1)Notably, 97.4% (111/114) of patients required at least one intervention during follow-up; 82.5% (94/114) required two or more interventions. The median number of interventions per patient was 3 (IQR 2-4). The type of intervention escalated with severity of grade, often requiring HBOT with variable response (Figure 2) but rarely progressing to vascular (angioembolization or iliac artery ligation) or surgical (cystectomy) procedures in refractory CHC. Median total costs rose approximately 7-fold from Grade 1 to Grade 2, 6-fold from Grade 2 to Grade 3, and 2-fold from Grade 4 to 5 adverse events. Mann–Whitney U test indicated significantly higher total costs among patients with at least one admission (median= ₹ 230,312, IQR ₹ 104,218– ₹ 432,617) compared to those without admission (median= ₹ 31,495, IQR ₹ 12,847– ₹ 98,504), U=230.0, Z=–7.86, p<.001, r=0.74.
Radiation-induced chronic haemorrhagic cystitis after cervical cancer radiotherapy: temporal course, impact of interventions and cost analysis. Ranjan Subramani 1 , Varsha Hande 2 , Gagan Prakash 3 , Sugam Ghodse 3 , Ankita Gupta 2 , Prachi Mittal 1 , Prachi Sawant 1 , Supriya Chopra 2 1 Department of Radiation Oncology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India. 2 Department of Radiation Oncology, ACTREC, Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, India. 3 Department of Urology Oncology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India Purpose/Objective: Moderate to severe radiation-induced chronic haemorrhagic cystitis (CHC) occurs in 6-8% of cervical cancer patients after radiotherapy1. Clinical data describing the longitudinal progression, management, morbidity and mortality and economic burden remain limited. Material/Methods: In this longitudinal time-course study, cervical cancer patients referred for cystoscopic evaluation for CHC between January 2018 and December 2024 were included. Patients with complete clinical, treatment, and follow- up records were analysed. CHC severity was graded using CTCAE v5.0 every six months to determine grade at onset, peak severity, and at last follow-up. Interventions (cystoscopy, Hyperbaric Oxygen Therapy [HBOT], angioembolization, iliac artery ligation, and cystectomy), blood transfusions, fulguration), admissions, and medications were recorded. Descriptive statistics summarized patient characteristics, interventions, grade of CHC, and costs. Mann–Whitney U test was used for group comparisons. Changes in CHC grade were categorized as progression, persistence,
Made with FlippingBook - Share PDF online