S436
Clinical - Gynaecological
ESTRO 2026
Mittal P, Gurram L, Ghosh SK, Gera P, Sawant S, Pullan S, Cheulkar D, Rahul N, Gupta A, Sawant P, Ghosh J. Prospective Observational Study To Compare Treatment Adherence And Acute Toxicities In Human Immunodeficiency Virus Positive Versus Negative Cervical Cancer Patients In India. International Journal of Gynecological Cancer. 2025 Feb 1;35(2). (https://doi.org/10.1016/j.ijgc.2024.100189) Keywords: Cervix carcinoma, HIV, Long term outcome Digital Poster 1929 Daily CBCT-based online adaptive external-beam radiotherapy with weekly MRI-guidance in cervical cancer: dosimetric impact and toxicity outcomes Jan-Hendrik Bolten 1,2 , Maximilian Knoll 1,2 , Felix H. Englert 1,3 , Justus Valentini 1,2 , Lars Wessel 1,3 , Jakob Liermann 1,3 , Nathalie Arians 1,3 , Eva Meixner 1,3 , Clara Meinzer 4 , Oliver Jaekel 1,2 , Heinz-Peter Schlemmer 2 , Juergen Debus 1,3 , Fabian Weykamp 1,2 1 Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany. 2 Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 3 Radiation Oncology, National Center of Tumor Diseases, Heidelberg, Germany. 4 Division of Radiology, German Cancer Research Center (DKFZ),
Heidelberg, Germany Purpose/Objective:
Definitive chemo- and immunoradiotherapy with brachytherapy is the standard of care for locally advanced cervical cancer.1 Daily variations in bladder and rectal filling, uterine position, and bowel displacement challenge treatment accuracy, necessitating generous PTV margins that increase dose to organs at risk (OAR) and risk toxicity.Online adaptive radiotherapy (oART) enables plan modification according to patient anatomy, potentially improving target coverage and reducing OAR dose. This study retrospectively analyzes dosimetric benefits and evaluates
Conclusion: Chemoradiation and BT was well tolerated in patients living with HIV and these patients should be treated with radical intent treatment for optimum disease control and long-term survival. References:
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