S444
Clinical - Gynaecological
ESTRO 2026
hematological toxicities [2], IMPT is a promising approach to reduce dose exposure to the pelvic skeleton and thus hematotoxicity.
2008;70(5):1431–1437 Keywords: Proton beam therapy, cervical & endometrial cancer
Poster Discussion 2175
From distress to desire: preliminary results of a prospective comparative study on psychological and sexual outcomes in cervical cancer Loredana Dinapoli 1 , Letizia Lafuenti 1 , Rebecca De Paola 1 , Alessia Lopriore 1 , Rosa Autorino 2 , Maura Campitelli 2 , Viola De Luca 2 , Raffella Rinaldi 2 , Fabio Marazzi 3 , Francesco Fanfani 4,5 , Anna Fagotti 4,5 , Giuseppe Colloca 3 , Luca Tagliaferri 3,6 , Daniela Chieffo 1,5 , Maria Antonietta Gambacorta 2,6 1 UOS di Psicologia Clinica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. 2 UOC Servizi di Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. 3 UOC Degenze di Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. 4 UOC di Ginecologia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. 5 Dipartimento di Scienze della vita e della salute pubblica, Università Cattolica del Sacro Cuore, Rome, Italy. 6 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy Purpose/Objective: Radiotherapy for cervical cancer is often associated with adverse physical effects, however, emerging evidence suggests that its psychological and sexual impact may be more complex than traditionally assumed (1- 2). Likewise, radical hysterectomy negatively affects the sexual function and psychological health of patients, and the effects can persist for a long time (3). This study examined emotional adjustment, sexual functioning, quality of life and dissociative experiences in women with cervical cancer undergoing
Conclusion: IMPT has already proven the capability of sparing gastrointestinal and genitourinary organs without compromising target volume coverage. The approach of reducing myelosuppression by bone marrow sparing through IMPT has the potential to reduce treatment interruptions, improve patients’ quality of life, and reduce long-term treatment-related complications. References: [1] Arians N, Lindel K, Krisam J, et al. Treatment tolerability and toxicity of postoperative proton beam therapy for gynecologic malignancies: results of the prospective phase 2 APROVE-trial. Int J Radiat Oncol Biol Phys. 2023;116(4):825–836.[2] Mell LK, Schomas DA, Salama JK, et al. Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys.
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