S466
Clinical - Gynaecological
ESTRO 2026
mm) and − 35% (PTV 5 mm).Plan libraries with 15-mm margins also showed moderate OAR sparing while being less time-consuming and resource-intensive: rectum V40Gy − 20%, bladder V40Gy − 13–25%, and bowel bag V40Gy − 5%.Additional adaptive strategies reported across the included studies are summarized in those figures.
Conclusion: Both offline and online adaptive strategies improve dosimetric accuracy compared to non-adaptive radiotherapy. Online ART, particularly daily replanning and PoD approaches, provides superior target conformity and OAR sparing, potentially reducing toxicity while maintaining tumor control. However, prospective clinical trials are needed to confirm these benefits and identify optimal candidates. Keywords: Cervical cancer, adaptive RT, dosimetric outcomes
Digital Poster Highlight 3307 Impact of EMBRACE-II Protocol
Radiotherapy Compliance on Clinical Outcomes in Locally Advanced Cervical Cancer: A Real-World Single-center Analysis Akrapol Suppasedtanon 1 , Pittaya Dankulchai 1,2 , Tissana Prasartseree 1,3 , Wiwatchai Sittiwong 1,2 , Pongpop Tuntapakul 1,2 , Wajana Thaweerat 1,2 , Pitchayut
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