S474
Clinical - Gynaecological
ESTRO 2026
contacts per month.Physical complaints were highly prevalent, including vaginal stenosis (77.9%), vaginal dryness (57.4%), and dyspareunia (39.7%). Sexual avoidance or abstinence was primarily motivated by the fear of disease relapse (60%), followed by the fear of contamination or pain (8.9% each).Sexual dysfunction prevalence was significantly higher in patients who reported an unhappy or slightly happy relationship before diagnosis (p=0.004 ; OR=5.3) and after diagnosis (p<0.001 ; OR=7.28). A negative partner reaction to the diagnosis and post- treatment sequelae significantly increased the risk of dysfunction (p=0.021 ; OR=5.78).Multivariate analysis revealed that the administration of brachytherapy was an independently predictive factor of sexual dysfunction(Adjusted OR 37.908; p=0.047). Body image disorders also significantly increased the risk (Adjusted OR 3.37; p=0.02). Conclusion: Uterine cancer and its treatment are strongly associated with a high prevalence of sexual dysfunction and adverse physical symptoms. These findings underline the urgent need to integrate comprehensive sexual counseling into the routine oncological care pathway for these patients. Keywords: Uterine cancer, sexual function Digital Poster 3504 Radiation-induced toxicities in obese patients with endometrial cancer: beyond BMI? Sanae Lamarti 1 , Fatima zahra Ouhida 1 , Hicham Gzenayi 1 , Ihssane Mninou 1 , Adil Gourinda 2 , Wafae Marsetti 1 , Soukaina Morchid 1 , Nabila Sellal 1 1 radiotherapy, Mohammed VI University Hospital, tangier, Morocco. 2 epidemiology, Mohammed VI University Hospital, tangier, Morocco
development of endometrial cancer[1].However, the precise link between body mass index(BMI)and postoperative radiation-related toxicity remains unclear. This study aims to clarify this association. Material/Methods: This is a retrospective study comparing the impact of BMI ≥ 30 kg/m ² than BMI<30 kg/m ² on tolerance to adjuvant radiotherapy in patients with endometrial cancer treated between April2017 and December2023 at the Radiotherapy Department, Mohammed VI University Hospital.Acute toxicities were graded according to the Common Terminology Criteria for Adverse Events(CTCAE). BMI categories were defined following WHO criteria. Results: A total of 71 patients were included. Among them,40%(n=28)had a BMI ≥ 30, with46% classified as class I,25%as class II,and 28%as class III obesity. The remaining 60%(n=43)had a BMI<30.The median age was 62years(32– 83years) in the obese group and60years (40– 73years)in the second group. Obese patients were more likely to have other comorbidities, particularly diabetes(35% vs.18%) and hypertension(18%vs.9%).Stage IB was predominant in both groups ,39%in obese patients versus 32%in the other group.External beam radiotherapy was delivered at doses of45–50 Gy using 3D-CRT in all obese patients and in 81% of non-obese ones.Brachytherapy was performed in 73% of cases, 38%of whom had BMI ≥ 30. 34(47%)patients, 58% of whom were obese,received chemotherapy based mainly on carboplatin-paclitaxel. Acute radiodermatitis occurred in 41% of cases(mostly grade1,69%), with 65% observed in obese patients. Radiation enteritis was reported in 57%(mostly grade 2,53%), including63% of patients with BMI ≥ 30. Radiation cystitis was noted in41%(mostly grade 1,75%), 58%of whom were obese. Regarding gynecologic toxicities, two obese patients developed grade 2 vulvovaginitis.A statistically significant
Purpose/Objective: Obesity is a well-established risk factor in the
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