S477
Clinical - Gynaecological
ESTRO 2026
consecutive and interrupted intervals.A reduction in tumor volume >90% at the end of EBRT (at fraction 25) was considered a good response. The Spearman rank correlation test assessed the association between cumulative interruption duration and end-of-EBRT response . Results: Sixteen women with mostly squamous cell carcinoma (87.5%), and FIGO stage IIB–IIIC1 (75%) were included. A total of 384 intervals from 400 treatment fractions were analyzed.The median [range] initial and final tumor volumes were 25.8 [3.4–78.8] cc and 0.7 [0 - 6.5] cc, respectively. As shown in figure 1, in the early phase, regression was significantly steeper during consecutive days (median = − 6.1 %/day) compared with interrupted intervals (median = − 3.5 %/day, p = 0.005). In the middle phase, slopes decreased ( − 4.2 %/day vs − 3.7 %/day, p = 0.144), and in the late phase, regression further slowed with no significant difference between interval types ( − 2.8 %/day vs − 2.6 %/day, p = 0.496). The cumulative duration of interruptions showed no clear association with tumor regression at fraction 25 ( ρ = 0.20, p = 0.45; Figure 2).
Conclusion: Treatment interruptions were associated with slower tumor regression, particularly early in treatment. They showed no clear impact on end-of-EBRT response in this cohort. Further studies with larger cohorts are needed to test this hypothesis further. Keywords: cervical cancer, MR-Linac, tumor regression Impact Of Nutrition on Clinical Outcomes in Endometrial Cancer Patients treated with Adjuvant Radiotherapy Arancha Gallego Barranco, Beatriz Gil Haro, Raquel Benlloch Rodriguez, Cristina de la Fuente Alonso, Sofía Santana Jiménez, Marta López Valcarcel, María Hernandez Miguel, Irma Zapata Paz, Joaquín Velasco Jiménez, María Isabel Garcia Berrocal, Irene Ávila Gómez, Jose Cantillana Barrenas, Susana Sánchez Rico, Peppa Abelairas, Maria Ángeles Ruiz, Jesús Romero Fernández, Sofía Córdoba Largo Digital Poster 3990 Radiation Oncology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain Purpose/Objective: To evaluate the association between skeletal muscle index (SMI) and treatment-related adverse effects, as well as clinical outcomes, in patients treated with adjuvant radiotherapy (RT) for endometrial carcinoma
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