S482
Clinical - Gynaecological
ESTRO 2026
showed no independent association. The mean overall QOL score was 50.65 ± 5.25. Sexual function was positively correlated with all QOL subdomains (p < 0.05). After adjusting for late radiation toxicities, FSFI remained a strong positive predictor of QOL (B = 1.77, β = 0.98, p < 0.001), while late radiation toxicities showed a minimal but statistically significant independent effect (B = 0.37, p = 0.035). Conclusion: Female sexual function and quality of life are markedly impaired among cervical cancer survivors in Bangladesh. Integrating sexual health assessment and supportive interventions into survivorship care is essential to improve reproductive health and overall well-being in this population. References: 1. Bae H, Park H. Sexual function, depression, and quality of life in patients with cervical cancer. Supportive care in cancer. 2016 Mar;24(3):1277-83.2. Johra RU, Ahsan MS, Sarkar AA. Cross-cultural adaptation and psychometric validation of the Female Sexual Function Index-6 (FSFI-6) Bangla version. Sexual Medicine. 2024 Jun;12(3):qfae044.3. Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol. 1993;11(3):570-9.4. FACIT Group. Functional Assessment of Cancer Therapy – General (FACT-G), Bangla version [Internet]. © 1997–2025. Available from: https://www.facit.org/measures/FACT-G Keywords: Cervical cancer, FSFI, Quality of life
Digital Poster 4348
Cervical cancer outcomes may be predicted by NGAL, a cancer-related glycoprotein that correlates with FIGO stage, operability,HPV subtype alterations. Behar I Raci 1,2 , Arta H Kameri-Jusufi 3 , Labinot Kastrati 4 1 Radiathion therapy, clinic oncology, Pristina, Albania. 2 Radiothen therapy, clinic oncology, Pristina, Albania. 3 Radiothen therapy, clinic oncology, pristina, Albania. 4 Faculty of Physics, Univeristy of Mitrovica, pristina, Albania Purpose/Objective: Particularly in low- and middle-income nations, cervical cancer continues to be a major worldwide health concern and a major source of morbidity and mortality among women. Even with improvements in screening and immunization programs, late- stage diagnoses still present significant difficulties. A tiny glycoprotein called neutrophil gelatinase-associated lipocalin (NGAL) is implicated in cancer-related processes such inflammation, cell differentiation, and death. It has been suggested as a biomarker for a number of cancers, although its function in cervical cancer is still unclear. This study examined the link between serum NGAL levels and FIGO stage, tumor operability, and HPV subtype distribution both before and after treatment in order to determine the diagnostic and prognostic importance of these levels in patients with cervical cancer. Material/Methods: Thirty of the 130 women in the research were healthy controls, and 100 had cervical cancer with histological confirmation. Before and after treatment, serum NGAL concentrations were assessed using a quantitative enzyme- linked immunosorbent test (ELISA). Real-time PCR was used for HPV genotyping, spanning 15 high- and low-risk HPV subtypes. NGAL readings were associated with clinical and
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