S493
Clinical - Gynaecological
ESTRO 2026
Keywords: hyperthermia, treatment planning
applicator position, amplitude, and phase settings—determined during clinical quasi- two-dimensional geometrical planning using standard Pyrexar Planing Software Tools for the hyperthermia system BSD 2000 (Pyrexar Medical, Salt Lake City, UT, USA)—were replicated in fully voxel-based finite- difference time-domain (FDTD) simulations. Additionally, three-dimensional (3D) optimization was performed based on the gross tumor volume (GTV) contour. Specific absorption rate (SAR) distributions within the GTV were compared between the original and optimized settings. Results: Simulations of the original treatment settings yielded a median SARMEAN (V) of 46.5 W/kg (range: 30.9-82.2 W/kg) and a SAR90 (SAR in 90% of the GTV) of 30.7 W/kg (range: 16.4- 51.4 W/kg). Optimization based on 3D target volume contours significantly improved both SARMEAN (median 55.7 W/kg, range: 30.8- 97.4 W/kg; p = 0.008) and SAR90 (median 36.55 W/kg, range 20.8-61.3 W/kg; p = 0.002, Assessment of SAR values in organs at risk, including the urinary bladder, rectum, and small bowel, proved safety of the HyperPlan planning
Digital Poster 5085
Summative dose feasibility of “Brachy- like” SBRT with MRgRT + VMAT 40Gy/20F + Image guided adaptive brachytherapy for cervical cancer: UPFRONTCx study Sajjaporn Pojai 1 , Tissana Prasartseree 1,2 , Eun Young Han 3 , Paritt Wongtrakool 1 , Belinda M Lee 3 , Sawanya Suwandee 1 , Napatsorn Thumyongkit 1 , Satawatchara Suwanprateep 1 , Natcha Nuchsirikulaphong 1 , Tanwiwat Jaikuna 1 , Pitchayut Nakkrasae 1 , Wiwatchai Sittiwong 1,2 , Christopher L Spicer 3 , Jinzhong Yang 3 , Zhiqian Henry Yu 3 , Ann H Klopp 2 , Yusung Kim 3 , Pittaya Dankulchai 1 1 Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. 2 Department of Radiation Oncology,, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3 Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA Purpose/Objective: To evaluate a novel induction "Brachy-like" SBRT technique, which may enhance tumour reduction and immunopotentiation before definitive chemoradiation and brachytherapy. Dose summation with VMAT 40Gy/20F + 3-fraction IGABT was explored with conventional summation and deformable-image-registration (DIR) dose summation. Material/Methods: Tencervical-cancer patients in Thai-single center were retrospectively re-optimized on the same initial planning CT. “Brachy-like” SBRT was planned on Monaco TPS to deliver high dose 16Gy/2F to “Virtual-tandem core PTV (VTC-PTV; core of HR-CTV Figure1)” and 7Gy/2F to HR-CTV on 1.5T MR-linac. The 2-arc VMAT was planned on RayStation to deliver
Conclusion: HyperPlan® effectively enhances the heating characteristics of phased-array system BSD 2000 for cervical cancer hyperthermia. These findings support its clinical imp
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