S496
Clinical - Gynaecological
ESTRO 2026
timing and patient selection for SRT in oligoprogressive ovarian disease. Keywords: SBRT, OVARIAN CANCER
Data from 228 patients were analysed. Median age was 65 years (range 35-87) and median follow up was 47 months (IQR 36-70). As per ESMO-ESTRO-ESP risk stratification, 131 (57 %) were high-risk, 44 (19 %) high- intermediate, 28(13 %) intermediate, and 25 (11 %) had advanced/metastatic disease who received EBRT after multi-disciplinary consensus. Seventy (31 %) patients had surgically staged node positive disease, and 112(50 %) patients received at least 2 cycles of adjuvant chemotherapy. At 2 years, DFS, LRFS and OS of the whole cohort were 70 %, 85 % and 89 % respectively. Univariate analysis of significant factors is illustrated in Figure 1. Eighty-six (37 %) patients developed recurrence of which the first recurrence type was locoregional only in 21 (24 %), distant only in 44 (52 %) and mixed relapse in 21 (24 %) patients. Recurrence occurred within 24 months in 88 % of mixed relapses, 81 % distant and 67 % locoregional recurrences. Of the locoregional recurrences, 4 were isolated vaginal vault, 4 were isolated lower vaginal, 3 were isolated pelvic, 9 were para-aortic nodal, and 1 was regional nodal + vaginal recurrence. Of the locoregional recurrences, 11 (52%) were infield, 7 (33%) marginal and 3 (14%) out of field as illustrated in Figure 2. Isolated marginal para-aortic recurrences only occurred in 4 patients. Patients with isolated lower-vaginal or para-aortic nodal relapses achieved better median post- recurrence survival (58 and 45 months, respectively) due to successful salvage therapy.
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Mapping Locoregional Failures After Adjuvant Radiotherapy in Endometrial Cancer: Prognostic factors and Radiotherapy Field-Based Patterns Jeyaanth Venkatasai 1 , Ayesha Sathali 1 , Aditya Agrawal 2 , Evi Markou 3 , Agamdeep Singh 4 , Sekinat Yusuf 1 , Priyanka Patel 1 , Benjamin Taylor 1 , Anna Winship 1 , Ingrid White 1 , Christopher Thomas 3 1 Clinical Oncology, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom. 2 Oncology, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom. 3 Medical Physics, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom. 4 General Medicine, Diwan Hospital, Himachal Pradesh, India Purpose/Objective: Analyse prognostic characteristics and locoregional recurrence patterns following adjuvant external beam radiotherapy (EBRT) in endometrial cancer (EC) patients. Material/Methods: Retrospective analysis of all patients treated with adjuvant pelvic EBRT for FIGO stage I-IV endometrial cancer of all histological subtypes from January 2018 to May 2023. In- field recurrence was defined as relapse within the radiotherapy field, marginal recurrence was relapse < 2 cms of the 95% isodose of radiotherapy and out-of-field ³ 2 cm. ESMO-ESTRO-ESP 2021 risk stratification was assigned and disease-free survival (DFS), locoregional recurrence free survival (LRFS) and overall survival (OS) were estimated using Kaplan-Meyer analysis. Different recurrence patterns across the subgroups were analysed with Pearson’s chi square test and Cox regression. Results:
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