S502
Clinical - Haemotology
ESTRO 2026
A prospective observational study was conducted in patients with histologically confirmed MF treated with TSEB at our center between December 2024 and May 2025. The Stanford TSEB technique uses low-energy electron beams to irradiate the entire skin surface, ensuring a uniform dose distribution through six patient positions. Radiotherapy schedules included 12 Gy in 8 fractions (47%) and 24 Gy in 8 fractions (53%). RECIST 1.1 criteria were applied to evaluate objective response. Functional performance and QoL were assessed using the EORTC QLQ-C30 questionnaire, and pain was measured with the visual analog scale (VAS). Statistical analysis was performed using paired t-test and chi-squared test. Results: A total of 15 patients were included, with a mean age of 67.7 years (range 35–84); 60% were male. Disease stages were I (26%), II (20%), III (20%), and IV (33.3%). Most patients (87%) experienced a progressive reduction in pain, and 53.4% required pharmacological treatment. The mean baseline VAS pain score decreased significantly from 5.47 to 2.2 at the end of treatment (p < 0.01). The mean EORTC QLQ-C30 global health score improved from 30 to 51 (p < 0.05), indicating better quality of life. Figure 1 shows additional EORTC QLQ-C30 results at baseline and end of treatment, demonstrating clinically significant improvements across most functional scales. Emotional Functioning increased from ~60 to 75 (p < 0.05), followed by significant improvement in Role Functioning. According to RECIST 1.1 criteria, disease control at the end of treatment was 89% (16% complete response, 48% partial, 25% stable, 11%
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Feasibility and early outcomes of VMAT based TMLI as conditioning regimen for Allogenic Stem Cell Transplant: A single institute experience Sharmila Agarwal 1 , Pragyashree PS 1 , Ritu Jain 2 , Jayant Ghoda Shastri 3 , Reena PH 3 , Siddharth Laskar 3 , Jai Prakash Agarwal 4 , Jayeeta Sen 1 , Sadanand Gaonkar 1 , Pallavi Patil 1 , Ganapathi Bhat 2 , Samir Shah 2 , Sunil Chopade 2 , Tapankumar Saikia 2 , Shreya Jalota 1 , Dipshi Agarwal 1 , Nikhil Kalyani 1 1 Radiation Oncology, Jaslok Hospital and research Centre, Mumbai, India. 2 Medical Oncology, Jaslok Hospital and research Centre, Mumbai, India. 3 Radiation Oncology, ACTREC, Mumbai, India. 4 Radiation Oncology, Tata Memorial Hospital, Mumbai, India Purpose/Objective: Total body irradiation (TBI) is a standard conditioning regimen for leukemia patients undergoing Allogenic Stem Cell Transplant (ASCT). Total Marrow and Lymphatic Irradiation (TMLI) is evolving in last few years to replace TBI as conditioning regimen with a purpose to reduce TBI associated toxicities. Material/Methods: We started offering VMAT based TMLI as a part of conditioning regimen since 2021 (We are the first in India to start VMAT based TMLI on TrueBeam STx). Between 2021-2025, we have planned 16 patients for TMLI and have treated 15 patients. Baseline characteristics, dosimetric parameters, toxicities and outcomes were recorded for all patients. Present analysis is a retrospective audit of these patients regarding feasibility and early outcomes.
progressive). Conclusion:
The treatment led to a significant reduction in pain intensity and a notable improvement in quality of life (QoL). These benefits were achieved without functional deterioration. Pain incidence in MF patients significantly impacts their QoL. Our study confirms Total Skin Electron Irradiation (TSEI) as a well-tolerated therapeutic option for MF patients. References: Navarro Matilla, B., Onteniente Gomis, M.D.M., Pujol Vallverdú, R.M., Combalia Escudero, A., Zapata Paz, I., Muniesa Montserrat, C & Ortiz Romero, P.L. (2022). EORTC - QLQ - C30 and SKINDEX - 29 measurement of health - related quality of life in patients with mycosis fungoides and Sézary syndrome: Real - world data in Spanish patients (MICADOS Study). JEADV Clinical Practice, 1(4), 438-449.Pujol RM, Gallardo F. Linfomas cutáneos - Parte I: Micosis fungoide, síndrome de Sézary y trastornos linfoproliferativos cutáneos CD30 +. Actas Dermo-Sifiliográficas [Internet]. 2021;112(1):14–23 Keywords: mycosis fungoides, cutaneous T-cell lymphoma
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