S526
Clinical - Haemotology
ESTRO 2026
Conclusion: TBI is a technique that provides effective control of disease while maintaining a low toxicity profile, making it a reliable choice for conditioning regimens for Hematopoietic Cell Transplantation. This treatment requires a multidisciplinary and expert team. Diagnosis and donor type were not related to survival. References: Negrin RS. Preparative regimens for hematopoietic cell transplantation. In: Chao N, Rosmarin AG (eds). UpToDate, vol. Topic 3557 Version 34.0. https://www.uptodate.com/contents/preparative- regimens-for-hematopoietic-cell-transplantation?. Accessed 10 October 2025Chao NJ. Survival, quality of life, and late complications after hematopoietic cell transplantation in adults. In: Negrin RS, Rosmarin AG (eds). UpToDate, vol. Topic 122403 Version 4.0. https://www.uptodate.com/contents/survival-quality- of-life-and-late-complications-after-hematopoietic-cell- transplantation-in-adults. Accessed 22 October June 2025. Keywords: TBI, hematopoietic cell transplantation Impact of Radiotherapy on Hematologic Toxicity and Autologous Stem Cell Transplant Efficacy in Patients with Multiple Myeloma Jacek Burzy ń ski Department of Brachytherapy and General Oncology, Copernicus Memorial Hospital, Ł ód ź , Poland, Copernicus Memorial Hospital, Lodz, Poland Purpose/Objective: Multiple myeloma (MM) is a plasma cell malignancy primarily affecting the bone marrow, with a median age at diagnosis of around 70 years. Although chemotherapy remains the mainstay of treatment, radiotherapy (RT) plays an important palliative role in the management of bone pain, prevention of Digital Poster 5009 pathological fractures, and spinal cord compression. Approximately 20–40% of MM patients receive RT during their treatment course. However, the hematologic toxicity associated with concurrent RT and novel combination chemotherapy regimens remains insufficiently characterized. The purpose of this study was to evaluate the impact of radiotherapy on hematologic complications, particularly neutropenia, and to assess whether RT influences stem cell mobilization and the course of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with multiple myeloma. Material/Methods: We retrospectively analyzed 55 multiple myeloma (MM) patients treated with radiotherapy at the Copernicus Memorial Hospital in Ł ód ź between 2020
1. Subsequently, a survival analysis was performed using Kaplan-Meier and long-rank tests to compare survival rates, as shown in Figure 2. No statistically significant differences were found in function of diagnosis or donor type.
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