S48
Brachytherapy - Gynaecology
ESTRO 2026
Interstitial applicators are not consistently available, and MRI is not commonly used for IGABT. It is reassuring that most clinicians do not substitute modern EBRT planning for BT. Strengthening training, infrastructure, and collaboration will be key to improving access to guideline-based care for women with LACC. The strong interest in regional cooperation offers opportunity to expand the use of advanced BT techniques. Keywords: Brachytherapy, practice pattern, Cervix cancer Short course adjuvant vaginal cuff brachytherapy (VCB) in early endometrial cancer compared to standard of care (SAVE) Aba Anoa Scott-Jackson 1 , Mary-Ann Dadzie 1 , Samuel Ntiamoah Boateng 1 , Emmanuel Asare Aning-Agyei 1 , Charles Akoto Aidoo 1 , Judith Naa Odey Tackie 1 , Lindsay Morgan Burt 2 1 Radiotherapy, Korle Bu Teaching Hospital, Accra, Ghana. 2 Radiation Oncology, University of Utah, Utah, USA Digital Poster 851 Purpose/Objective: Conventional vaginal cuff brachytherapy (VCB) regimen for endometrial cancer require multiple treatment sessions (3–5 fractions), which can increase patient burden and healthcare costs. The purpose of the study was to evaluate the non inferiority of short course VBC to other standard regimen in early stage endometrial carcinoma. Material/Methods: This was a phase II, unblinded, randomized clinical trial designed to compare short course VCB (11 Gy x 2 fractions at the surface) with other standard regimens (7 Gy x 3 fractions at 0.5 cm depth, 6 Gy x 5 fractions at the surface, or 5-5.5 Gy x 4 fractions at 0.5 cm depth). The primary endpoint was to evaluate the non- inferiority of Health-Related Quality of Life (HRQOL) in the experimental arm compared with the control arm, as measured by the Global Health Score using EORTC QLQ-C30 with a pre-specified non-inferiority margin of 10 points. Secondary endpoints included assessment of cost-effectiveness and treatment-related toxicities between the two treatment arms assessed by CTCAEv4. Data were collected at each brachytherapy fraction and at 1, 6, and 12 month follow-up Results: 16 patients were enrolled, 8 in each study arm. Data completion was 100% at 1 month, 6 months, and 12 months. [LB1]All patients had endometrioid histology with a mean age of 65 years (sd- 8). Majority of the patients were stage 1 (50% 1a and 37.5% 1b). The QLQ-C30 Global Health Status for the experimental
with MRI-based planning in 15%. Combined intracavitary–interstitial techniques were available in 58%, hybrid applicators in 46%. Overall treatment time was ≤ 56 days in 53.2% and >8 weeks in 32.9%.
Key barriers were shortages of trained personnel, limited access to applicators, and logistical constraints. More than half of respondents expressed willingness to share expertise in BT planning.
Conclusion: This first multi-regional survey shows that BT is widely available across MENAT- ASP region, with HDR as the standard of care. Practice varies between centres.
Made with FlippingBook - Share PDF online