S554
Clinical – Head & neck
ESTRO 2026
Proffered Paper 932 Low-level laser therapy for radiation-induced oral mucositis: a prospective clinical trial (IRCT20191107045357N2) Ahmad Ameri 1 , Mansour Lesan 1 , Vahideh Vafaei 1 , Farzad Taghizadeh-Hesary 2,3 , Nazanin Rahnama 4 , Zeinab Abiar 1 , Atieh Sadat Hashemi 1 , Simin Badiei Moghaddam 1 , Ardeshir Matoofi 1 , Seyedeh Shaghayegh Rezvani Nezhad 1 , Seyed Saeed Hashemi Nazari 5,6 1 Clinical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of. 2 Head and Neck Research Center and Department, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of. 3 Breast Cancer Research Center, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of. 4 Department of Radiation Oncology, University Hospital of Zürich, Zürich, Switzerland. 5 Prevention of Cardiovascular Disease Research Center, Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of. 6 Safety Promotion and Injury Prevention Research Center, Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of Purpose/Objective: To evaluate the therapeutic effect of low-level laser therapy (LLLT) on established radiation-induced oral mucositis (OM) in head and neck cancer (HNC) patients undergoing radiotherapy Material/Methods: In this prospective, double-blind, self-controlled clinical trial, 53 HNC patients with two comparable OM lesions were included. One lesion received LLLT (660 nm, 150 mW, 5 J per point, twice weekly), while the contralateral lesion received sham treatment. OM severity and pain were assessed weekly using the Oral Mucositis Assessment Scale (OMAS) and the Visual Analog Scale (VAS) until complete healing or two weeks after radiotherapy. Results: LLLT significantly reduced OM severity and pain compared with control lesions. Pain reduction was observed from the first week, whereas OMAS improvement became significant from week three. Complete healing occurred in 52.4% of LLLT-treated lesions versus 11.9% of controls (P < 0.001). No adverse effects were observed. Conclusion: LLLT is a safe and effective therapeutic approach for radiation-induced OM in HNC patients. Early and continued application accelerates healing, reduces pain, and may improve tolerance to radiotherapy. Keywords: low-level laser therapy; oral mucositis
Conclusion: An explainable model could predict muscle loss after radiotherapy for oral cavity cancer and identify important contributors to muscle loss. Personalized predictions may assist tailor radiotherapy to reduce the risk of muscle loss. References: 1. van Heusden HC et al. The predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta- analysis. Br J Cancer. 2025;133(2):131-43.2. Lee J et al. Identifying threshold of CT-defined muscle loss after radiotherapy for survival in oral cavity cancer using machine learning. Eur Radiol. 2025;35(7):4289-99. Keywords: Oral cavity cancer, Prediction, Muscle loss
Made with FlippingBook - Share PDF online