S616
Clinical – Head & neck
ESTRO 2026
Methods: Our phase II prospective study enrolled newly diagnosed patients with nasopharyngeal carcinoma who received definitive intensity- modulated radiation therapy (IMRT). Patients were stratified into a low-risk group (total score = 0–2.5) and a high-risk group (total score = 4–8.5) based on a risk score model (RSM) derived from our previous studies. The RSM scores were assigned as follows: A score of 2 was allocated for involvement of the anterior half of the nasal cavity, 2.5 for involvement/compression of the submandibular glands (SMGs), and 4 for either a maximal axial diameter (MAD) of level IIA lymph nodes >20 mm or extracapsular spread (ES) of level IIA lymph nodes. Survival outcomes focused on overall survival(OS), local recurrence-free survival(LRFS), regional relapse-free survival(RRFS), distant metastasis-free survival(DMFS) and disease-free survival(DFS). Results: Results: A total of 116 patients were enrolled in this study, with a median follow-up time of 59 months (range: 5–77 months). Among them, one patient in the high-risk group and one patient in the low-risk group developed recurrence in level IB lymph nodes. The 5- year OS, LRFS, RRFS, DMFS and DFS rates were 88.37%, 90.37%, 96.15%, 87.75% and 80.06%, respectively.
Patients with regular MDA attendance demonstrated improved treatment adherence and lower rates of Grade 3 (severe) dysphagia and odynophagia. Advanced tumour stage was associated with lower attendance and higher toxicity grades. No significant differences in attendance were observed by age, gender, or tumour site. Conclusion: High attendance at multidisciplinary appointments was associated with improved treatment adherence and fewer severe swallowing toxicities among patients receiving curative-intent RT for HNC. These findings reinforce the importance of multidisciplinary collaboration and consistent patient engagement throughout treatment. Interventions such as brief educational videos introducing the multidisciplinary team, flexible scheduling, and enhanced communication strategies may further promote attendance and optimise patient outcomes. Future work should prospectively assess barriers to participation and evaluate the long-term impact of multidisciplinary engagement on functional recovery and quality of life. References: (1) De Felice, F., Tombolini, V., de Vincentiis, M., Magliulo, G., Greco, A., Valentini, V., & Polimeni, A. (2018). Multidisciplinary team in head and neck cancer: a management model. Medical oncology, 36(1), 2. https://doi.org/10.1007/s12032-018-1227-z Keywords: Patient participation, clinic attendance, outcome Mini-Oral 3210 A prospective study on risk model-based individualized irradiation of level IB region in nasopharyngeal carcinoma (Registration No. ChiCTR1800015880) Qi-Wei Luo 1,2 , Zi-Wei Tu 3 , Lei Zeng 1 1 Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. 2 Department of Radiation Oncology, Guangdong Provincial People's Hospital Ganzhou Hospital, Ganzhou Municipal Hospital, Ganzhou, China. 3 Department of Radiation Oncology, GuangdJiangxi Cancer Hospitalong Provincial People's Hospital Ganzhou Hospital, Ganzhou Municipal Hospital, Nanchang, China Purpose/Objective: Objective: This study aims to investigate the indications for prophylactic irradiation of Level IB nodes in patients with nasopharyngeal carcinoma(NPC) treated with intensity-modulated radiation therapy (IMRT). Material/Methods:
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