S618
Clinical – Head & neck
ESTRO 2026
Conclusion This first study on MR-only planning workflow for H&N radiotherapy supports the feasibility, reproducibility and robustness of this approach. sCT- to-CBCT registration appears achievable, provided that T1-to-sCT registration is repeated in case of patient movement, or re-positioning is performed when misalignments are excessive. Digital Poster 3272 Impact of radiotherapy on quality of life in squamous cell carcinomas of the head & neck, anal canal and cervix: Results from MORRIS NCT02379039 Petter Sundin 1 , Björn Zackrisson 1 , Per Fransson 2 , Kristina Lundquist 3 , Karin Söderkvist 1 1 Oncology, Institution of diagnostics and interventions, Umeå, Sweden. 2 Oncology, Department of Nursing, Umeå, Sweden. 3 Chemistry, Department of Chemistry, Umeå, Sweden Purpose/Objective To assess the impact on health-related quality of life (HRQoL) after curative radiotherapy (RT) for non- cutaneous squamous cell carcinoma (SCC) at 12 months after RT, in comparison to baseline results. Material/Methods During 2015-2021, 118 consecutive patients intended for definitive RT diagnosed with previously untreated non-cutaneous SCC treated at a tertiary care center are included in this prospective observational study of multimodal monitoring of response. The study comprised SCC of the head & neck (HNSCC), anal-canal and uterine cervix. Each subsite is treated in accordance with clinical practice for the tumor site. Treatment is administered with VMAT technique (with high priority dose constraints for contralateral parotid for HNSCC patients). HRQoL is assessed with EORTC quality of life questionnaire QLQ-C30 and QLQ-HN35 at baseline and 12 months after start of treatment (1,2). Scores are reported as mean values and comparisons are performed using paired t-test. Change of 10 points or more on the EORTC-scale has been shown to be clinically meaningful (3).
Results 64 patients had completed the QLQ at baseline and 52 completed QLQ after one year. Overall, physical functioning deteriorated (4 points, p-value 0.023). Emotional functioning (9 points, p-value 0.003) and insomnia (7 points, p-value 0.027) improved and there was a trend towards increased global health status (7 points, p-value 0.075). For patients with HNSCC 6 of 18 symptom scales showed clinically significant change. Most notably, clinically significant increase of dry mouth and sticky saliva occurred with increase by 46 and 31 points respectively (p-value <0.001). Significant deterioration was observed in the taste and smell domain (19 points, p-value 0.003). Patients with HPV-negative disease had clinically significant worsening in 10 of 15 parameters from the EORTC QLQ-C30 questionnaire, compared to 2 of 15 for patients with HPV-positive disease. There was no association between relevant HRQoL-parameters and relapse in univariate linear regression analysis. Patients with tumors in the pelvis area reported significant improvement in global health status (16 points, p-value 0.013) and a trend towards increased problems with diarrhea (10 points, p-value 0.052).
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