S629
Clinical – Head & neck
ESTRO 2026
in-field, marginal and out-of-field failures, respectively. Using CTV-P2 volume, 20 (77%), 5 (19%), and 1 (4%) had in-field, marginal and out-of-field failures, respectively. Utilizing the COM as the reference, 23 (88%) of the failures were in-field, with the remaining 3 (12%) out-of-field. Conclusion: Local failure is the most common pattern of failure in patients with laryngeal cancer treated with IMRT. The pattern of failure remained the same using various evaluation criteria, such as 95% isodose line, CTVP1, CTVP2 and COM. This predominance of in-field failures and low numbers of marginal failures, therefore, confirms the adequacy of margins such as CTVP1 and CTVP2 as proposed by Gregoire et al, which have been implemented worldwide. References: [1] V. Grégoire et al.Radiother. Oncol., vol. 126, no. 1, pp. 3–24, Jan. 2018, doi: 10.1016/j.radonc.2017.10.016.[2] L. A. Dawson et al.Int. J. Radiat. Oncol., vol. 46, no. 5, pp. 1117–1126, Mar. 2000, doi: 10.1016/S0360-3016(99)00550-7.[3] K. S. C. Chao et al.Int. J. Radiat. Oncol., vol. 55, no. 2, pp. 312– 321, Feb. 2003, doi: 10.1016/S0360-3016(02)03940- 8.[4] S. A. S. Raktoe et al.Int. J. Radiat. Oncol., vol. 85, no. 1, pp. 136–141, Jan. 2013, doi: 10.1016/j.ijrobp.2012.02.042.[5] A. S. R. Mohamed et al. Radiat. Oncol., vol. 11, no. 1, p. 95, Jul. 2016, doi: 10.1186/s13014-016-0678-7. Keywords: Patterns of Failure, Laryngeal Cancer, IMRT Clinical Outcomes of Post-cricoid Cancer treated with VMAT-based ChemoRadiotherapy: Insights from a high-burden region Rohit Avinash Vadgaonkar 1 , Sneha Nachu 1 , Nandini Sekhar 2 , Chandrasekhar Pusarla 1 , Sasi Krishna Kavutarapu 3 , N Nageswara Rao 3 , Neeharika Alapati 4 , Rajeswari Prem 5 , Samyak Jain 1 , Sonali Susmita Nayak 6 , Anupurva Dutta 6 , Vidya Viswanath 7 , Kiriti Chiriki 1 , Raghvendra Hajare 1 , Abhilasha R 1 , Raviteja Miriyala 1 , Umesh Mahantshetty 1 Digital Poster 3656 1 Radiation Oncology, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India. 2 Speech and swallow therapy, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India. 3 Head and neck Surgical Oncology, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India. 4 Medical Oncology, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India. 5 Nutrition, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India. 6 Pathology, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India. 7 Palliative care medicine, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, India
carcinoma of oropharynx and pharyngolarynx. Radiother Oncol. 1985;3(3):245–55.3.Lindberg R. Distribution of Cervical Lymph Node Metastases From Squamous Cell Carcinoma. Cancer. 1972;1446–9. Keywords: oropharynx, radiotherapy, nodal involvement
Digital Poster 3651
Patterns of Failure in Laryngeal Cancers Treated with Intensity-Modulated Radiation Therapy Alan Paul 1 , Ashwini Budrukkar 1 , Mangesh Ikhe 2 , Shrikant Kale 3 , Monali Swain 1 , Sarbani Ghosh Laskar 1 , Rituraj Upreti 3 , Samarpita Mohanty 1 , Shwetabh Sinha 1 , Anuj Kumar 1 , Jai Prakash Agarwal 1 1 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. 2 Department of Radiation Oncology, Solapur Cancer Center, Solapur, India. 3 Department of Medical Physics, Tata Memorial Hospital, Mumbai, India Purpose/Objective: The aim of this single-institution study was to evaluate the patterns of failure at the site of primary carcinoma of the larynx treated using intensity-modulated radiation therapy (IMRT) in relation to CTV-P1 and CTV- P2 as defined by Gregoire et al. [1]. Material/Methods: Patients treated for laryngeal cancers with definitive radiotherapy using IMRT technique with or without concurrent chemotherapy from January 2013 to December 2024 were considered suitable for the study. The data was collected from the electronic medical records, Radiation Oncology information system and Eclipse treatment planning system. The local failures were categorized into in-field, marginal and out-of-field based on three methodologies given by Dawson et al (95% isodose volume)[2], Chao et al (CTV P1 and CTV P2)[3], and Raktoe et al (Centre of mass-COM)[4], [5]. The original methodology proposed by Chao et al was modified for primary Clinical Target Volume (CTV)s both CTV-P1 and CTV-P2 in order to check the adequacy of the guidelines given by Gregoire et al[1]. Results: During the study period, 149 patients were treated using definitive IMRT with or without concurrent chemotherapy for laryngeal cancers, out of which 49 failures were found. The predominant pattern of failure was local, seen in 34 (70%) patients However recurrence scans were available for 26 patients and form the cohort for further evaluation. Using the criteria given by Dawson et al , 22 (85%), 4 (15%), and 0 (0%) had in-field, marginal and out-of-field failures, respectively. Using the criteria given by Chao et al with CTV-P1 as reference, 19 (73%), 5 (19%), and 2 (8%) had
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