S646
Clinical – Head & neck
ESTRO 2026
Weight loss and serum albumin change were comparable between groups. These findings support that adoption of the ‘5+5 mm’ approach maintains nutritional tolerance and reduces acute treatment- related morbidity in patients treated with CRT. References: 1. Grégoire V, Evans M, Le QT et al. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2018 Jan;126(1):3-24. doi: 10.1016/j.radonc.2017.10.016. Keywords: 5+5 mm technique, target delineation, nutrition Defining predictive immune signatures by immune monitoring and machine learning from the blood of HNSCC patients in the prospective DIREKHT01 trial Anna-Jasmina Donaubauer 1 , Oliver Tomic 2 , Sarina K. Müller 3 , Cecilia M. Futsaether 2 , Kristian Hovde Liland 2 , Bao Ngoc Huynh 4 , Jens Von Der Grün 5,6 , Panagiotis Balermpas 5,6 , Claus Rödel 6 , Matthias G. Hautmann 7 , Felix Steger 7 , Thomas Hehr 8 , Carmen Stromberger 9 , Volker Budach 9 , Markus Schymalla 10 , Lukas Kocik 11 , Hans Geinitz 11,12 , Ursula Nestle 13 , Gunter Klautke 14 , Charlotte Frei 15 , Stefanie Corradini 15 , Rainer Fietkau 15 , Udo S. Gaipl 1 , Benjamin Frey 1 , Marlen Haderlein 15 1 Translational Radiobiology, Department of Radiation Oncology, Universitätsklinikum Erlangen, Erlangen, Germany. 2 Faculty of Science and Technology, University of Life Sciences, Ås, Norway. 3 Department of Otolaryngology - Head & Neck Surgery, Universitätsklinikum Erlangen, Erlangen, Germany. 4 Department of Medical Physics, Oslo University Hospital, Oslo, Norway. 5 Department of Radiation Oncology, Zurich University Hospital, Zürich, Switzerland. 6 Department of Radiation Oncology, University Hospital Frankfurt, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany. 7 Department of Radiotherapy and Radiation Oncology, University Hospital of Regensburg, Regensburg, Germany. 8 Department of Radiotherapy and Radiation Oncology, Marienhospital Stuttgart, Stuttgart, Germany. 9 Department of Radiotherapy and Radiation Oncology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. 10 Department of Radiotherapy and Radiation Digital Poster Highlight 4065 Oncology, University Hospital of Marburg, Marburg, Germany. 11 Department of Radiation Oncology and
(72%) and 20 (67%) patients in each cohort, respectively. Baseline characteristics are
demonstrated in Table 1. Median percentage weight loss during treatment was -7.2% (IQR -11.0 to -4.7) and -8.5% (IQR -10.9 to -6.4) for the pre-5+5 and 5+5 groups, respectively (p=0.373). Median change in serum albumin was -5 g/dL (IQR -8 to -3) and -4 g/dL (IQR -8 to -2), respectively (p=0.535). Amongst patients with feeding tubes, median dwell time after end of treatment was 123 days (IQR 85 – 208) for the pre 5+5 cohort (n=24) and 100 days (IQR 44 – 131, n=22) for the 5+5 cohort (p=0.064). In those who received CRT, median tube dwell time was 151 days (IQR 90 – 209) for pre 5+5 cohort (n=17) and 76 days (IQR 42 – 121, n=16) for the 5+5 cohort (n=16) (p=0.023).
Conclusion: In our centre, implementation of the ‘5+5 mm’ technique was associated with a trend toward reduced feeding tube dwell time, with statistically significant difference in patients who were treated with CRT.
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