S672
Clinical – Head & neck
ESTRO 2026
proportional hazard models were used to test their association with age-subgroup, smoking history, ECOG PS, TNM stage, CCI and ACE-27, respectively. A p-value <0.05 was considered statistically significant. Results: After matching, a cohort of 76 pts was included in our analysis. Overall, the median age was 79.5 years (range 70-88), most pts had ECOG PS 0-1 and stage II- III disease (according to TNM 8th edition), representing 89,5% and 52,6% pts, respectively. Median Charleson Comorbidity Index and Adult Comorbidity Evaluation- 27 overall score were 2 (range 0-9) and 2 (range 0-3), respectively. Older patients were more frequently
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Older patients with HPV-positive oropharyngeal cancer: prognostic factors from a multicentric mached-cohort analysis. Marco Banini 1 , Viola Salvestrini 1 , Olga Ruggieri 1 , Carlotta Becherini 1 , Isacco Desideri 1 , Liliana Belgioia 2 , Marta Maddalo 3 , Giuseppe Fanetti 4 , Paola De Franco 5 , Silvia Bertocci 6 , Francesca De Felice 7 , Stefano Ursino 8 , Anna Merlotti 9 , Daniela Alterio 10 , Nicola A Iacovelli 11 , Francesco Micciché 12 , Elisa D'Angelo 13 , Lorenzo Livi 1 , Pierluigi Bonomo 1 1 Radiation Oncology Department - Careggi Hospital, University of Florence, Florence, Italy. 2 Health Science Department - Radiation Oncology, University of Genoa, Genoa, Italy. 3 Radiation Oncology, Department of Medical and Surgical Specialties, Radiological Science and Public Health, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy. 4 Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. 5 Radiation Oncology, Ospedale Vito Fazzi, Lecce, Italy. 6 Radiation Oncology, Ospedale San Donato, Arezzo, Italy. 7 Radiation Oncology, University Hospital La Sapienza, Rome, Italy. 8 Radiation Oncology, University Hospital Santa Chiara, Pisa, Italy. 9 Radiation Oncology, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy. 10 Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy. 11 Radiotherapy 2 Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 12 Diagnostica per Immagini, Radiation Oncology and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 13 Radiation Oncology, University Hospital of Modena, Modena, Italy Purpose/Objective: Little is known about survival, treatment outcomes of older patients (pts) affected by locally advanced HPV- related Oropharyngeal Carcinoma (OPC) and how comorbidity and frailty may impact. Here, we present the results of a matched cohort analysis between middle-old and oldest old patients from a multicentric trial. Material/Methods: An observational retrospective study was conducted for pts treated between 2012 and 2023. Consecutive patients older than 70 years at diagnosis with a histologically-confirmed HPV+ (p16 immunohistochemistry/HPV DNA-in situ hybridization) OPC eligible for a curatively-intended treatment were included. Middle-old (age 70-79) and oldest-old (age ≥ 80) pts were matched according to ECOG PS and tumor stage. Median Overall Survival (OS), Progression Free Survival (PFS) and Locoregional Recurrence-free survival(LR-RFS) were estimated with the Kaplan- Meyer method, while log-rank test was used for subgroups comparisons and Cox regression and Cox
treated with exclusive RT (p=.001). Clinical characteristics were overall balanced and
aresummarized in table 1. After a median follow- up of 24.5 months (range: 1-118), 60% of pts were alive, with a median OS of 60 months, relapse had occurred in 35.5% of pts (median PFS not reached), while only 19.7% patients had LR relapse (median LR-RFS not reached). Interestingly, after adjusting for other clinical factors, age subgroup wasn’t significantly associated with any survival outcome (p=.086 for OS; p=.96 for PFS; p=.543 for LR-PFS). ECOG-PS was associated with OS (HR 2.50, 95CI 1.29-4.85, p=.006) and TNM stage was associated with PFS (HR 2.22 95CI 1.39-2.95, p=.001), while ACE-27 showed association with OS only at univariate analysis (HR 1.66, 95CI 1.07-2.56, p=.022).
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