S709
Clinical – Lower GI
ESTRO 2026
CI (7.8%, Inf). Pre-specified adjusted multivariable logistic regression with imputed data produced an odds ratio 2.27 (80% one-sided CI (1.54, inf), one-sided p-value 0.038), statistically significant at the one-sided 20% level. Pre-defined sensitivity analyses including cCR data outside the +/- 5-week window (15 (41.7%) SDRT vs 46 (59.7%) EDRT) and a modified cCR allowing superficial mucosal ulceration (13 (36.1%) SDRT vs 44 (57.1%) EDRT) showed similar significant results.
Conclusion: EDRT demonstrated a statistically significant and clinical meaningful increase in 6-month cCR rate, representing the first randomised report showing early benefit of external beam dose escalation in early rectal cancer. Keywords: Rectal cancer, organ preservation, dose escalation
Digital Poster 2344
Real-world implementation of total neoadjuvant therapy and organ preservation in rectal cancer: insights from the SEOR-GI national survey. Sigfredo E Romero Zoghbi 1,2 , Fernando López Campos 3,4 , Abrahams Ocanto 5,6 , Margarita Martín Martín 3 , Cristina Laria 1 , Daniela Gonsalves 5,6 , Barbara G Salas Salas 7 , Laura Ferrera - Alayón 7 , Belén Belinchón Olmeda 3 , María Belén Ríos Pozo 8 , Andrea Bobo Jaureguizar 9 , María Dolores De Las Peñas Cabrera 10 , Maria Victoria De Torres Olombrada 11 , Esther Jiménez - Jiménez 12 , Maria Antonieta Gómez Aparicio 13 , Maria Luisa Hebrero Jiménez 14 , Iñigo San Miguel Arregui 15 , Elías Gomis Sellés 16 , Diego F Rincón Cruz 17 , Javier Valencia Julve 18 , Patricia Sarrión Rubio de la Torre 19 , Javier Peinado Serrano 20 , Jon Andreescu Yagüe 21 , Olwen Leaman Alcibar 22 , Felipe Couñago 5,6
Made with FlippingBook - Share PDF online