S864
Clinical - Mixed sites & palliation
ESTRO 2026
propensity scores to balance baseline factors. An IPTW-adjusted multivariate logistic regression analysis, including low PMI, intestinal V10 Gy, performance status, and gender, was conducted to identify predictors for anorexia.
Conclusion: In abdominal palliative radiotherapy,low PMI is a strong and independent predictor of acute anorexia, regardless of intestinal radiation dose. Pre-treatment assessment of sarcopenia using PMIscore may provide valuable information for predicting and managing treatment-related toxicities in palliative radiation therapy. References: 1. Huang F, Ma M, Lang L, Yang S, Zhao H, Zhang J, et al. Impact of sarcopenia on the prognosis of patients with advanced non - small cell lung cancer treated with antiangiogenic therapy: A propensity score matching analysis. Thorac Cancer. 2024 Nov;15(31):2248–59. 2. Zhang Y, Zhang J, Zhan Y, Pan Z, Liu Q, Yuan W. Sarcopenia is a prognostic factor of adverse effects and mortality in patients with tumour: A systematic review and meta - analysis. J Cachexia Sarcopenia Muscle. 2024 Dec;15(6):2295–310. 3. Holyoake DLP, Partridge M, Hawkins MA. Systematic review and meta-analysis of small bowel dose–volume and acute toxicity in conventionally-fractionated rectal cancer radiotherapy. Radiother Oncol. 2019 Sept;138:38–44. Keywords: sarcopenia; gastrointestinal toxicity; IPTW
Results: The median prescribed dose was 32.5 Gy (range, 3.25- 50 Gy). Of the 144 patients, 33 (22.9%) were classified as the normal PMIgroup and 111 (77.1%) as the low PMI group. Among acute GI toxicities, only anorexia showed a significant increase in the low PMI group compared with the normal PMI group (34.2% vs. 9.1%, P=0.004). Before IPTW adjustment, thelow PMI was significantly associated with anorexia (odds ratio [OR] 5.78, P=0.008). After IPTW, the lowPMI remained an independent predictor of anorexia (OR 4.98, P=0.011) (Table1). In contrast, intestinal V10 Gy were not significantly correlated with anorexia.
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