S873
Clinical - Mixed sites & palliation
ESTRO 2026
Deodato 1,13 , Antonio Pontoriero 14 , Francesco Cellini 15,16 , Ernesto Maranzano 17 , Alessio Giuseppe Morganti 9,10 , Vincenzo Ravo 4 , Rossella di Franco 4 1 Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy. 2 Department of Health Sciences (DISSAL), University of Genova, Genova, Italy. 3 Radiation Oncology Departmen, IRCCS Ospedale Policlinico San Martino, Genova, Italy. 4 Department of Radiation Oncology, Istituto Nazionale Tumori-IRCCS- Fondazione G. Pascale, Naples, Italy. 5 Medical Physics Unit, Responsible Research Hospital, Campobasso, Italy. 6 Radiation Oncology Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy. 7 Department of Radiation Oncology, RCCS San Raffaele Scientific Institute, Milan, Italy. 8 Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy. 9 Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy. 10 Radiation Oncology, IRCCS Azienda Ospedaliero- Universitaria di Bologna, Bologna, Italy. 11 Department of Radiation Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy. 12 Department of Radiation Oncology, Santa Maria della Misericordia Hospital, Rovigo, Italy. 13 Istituto di radiologia, Università cattolica del Sacro Cuore, Roma, Italy. 14 Radiation Oncology Unit, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy. 15 Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Università Cattolica del Sacro Cuore, Roma, Italy. 16 Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Roma, Italy. 17 University of Perugia, University of Perugia, Perugia, Italy Purpose/Objective: We report the preliminary results of first 84 patients of a Multicentric Retrospective Study focusing on the Re- Irradiation of Spinal Metastases (RIMESPINE trial). Material/Methods: We retrospectively collected clinical and dosimetric data of patients who underwent spinal reirradiation between September 2009 and October 2024. The primary endpoint was to evaluate the incidence of this type of treatment, its safety profile and local control rates. Results: 84 patients (M/F ratio: 46/38, median age: 49 years; range: 37-92), accounting for 90 lesions, were enrolled in 7 Italian centres. The majority of patients (73/84) had a life expectancy >6 months and the main primary tumors were lung (25%), prostate (20%) and breast cancer (19%). The lesions (lytic 49, non-lytic 12, mixed 39) were mainly located in the dorsal (38%) and
lumbar (32%) spine, predominantly involving the vertebral body (64%); vertebral deformation was present in 25 cases. Pain was registered in 70 cases (55 patients with a VAS>5), while neurological symptoms in 22 cases. The median interval between the first and second RT was 20 months (1-133). A total of 11 different fractionation schedules were used for the reRT, mainly 8Gy in 1 fx (47%), 12 Gy in 4 fx (12%), and 25Gy in 5fx (11%). Median PTV was 53.3 cc (4.57- 1015.6) and the main prescription method was at the one to the isodose. The median cumulative dose to the thecal sac in EQD2 (alpha/beta 3) was 34 Gy (8.2- 72.0). Only one acute toxicity was reported (a G1 pain flare) and no late toxicity. Pain reduction was recorded in 48 cases and neurological symptoms resolution in 11/22 patients. LC and OS at one years were 71.0% and 49.3%, respectively. Conclusion: Spinal reRT appears to be a safe practice, provided there is careful patient selection. Keywords: Reirradiation, spine, multicenter study Effectiveness of palliative radiotherapy in nonagenarian patients with head and neck cancers. Anna Bandurska-Luque 1 , Adam Kluska 2 , Tomasz Winiecki 1,3 , Piotr Wojnicz 1 , Ma ł gorzata Jankowska 1 , Joanna Kazmierska 1,4 1 Radiotherapy department II, Greater Poland Cancer Centre, Poznan, Poland. 2 Brachytherapy Department, Greater Poland Cancer Centre, Poznan, Poland. 3 Doctoral School of Molecular Medicine, Medical University of Lodz, Lodz, Poland. 4 Department of Electroradiology, Poznan University of Medical Sciences, Poznan, Poland Purpose/Objective: The aim of the study was to assess the effectiveness of palliative radiotherapy (RT) in patients aged 90 years and older with head and neck cancers. Material/Methods: We conducted a monocentric, retrospective analysis to Digital Poster 1455 identify patients >= 90 year old treated with RT between January 2019 and July 2025 in our hospital department and ambulant care unit. ECOG performance status, score for G-8 geriatric screening tool [1., 2.], grade 3-4 adverse events, overall survival (OS) and time to progression (TTP) were assessed. Results: Twenty five patients diagnosed with head and neck
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