S876
Clinical - Mixed sites & palliation
ESTRO 2026
1 Radiation Oncology, ICO Badalona, Barcelona, Spain. 2 Medical Oncology, ICO Badalona, Barcelona, Spain. 3 Urology, Germans Trias i Pujol University Hospital, Barcelona, Spain. 4 General Surgery, Germans Trias i Pujol University Hospital, Barcelona, Spain. 5 Radiology, Germans Trias i Pujol University Hospital, Barcelona, Spain Purpose/Objective: Following the integration of MRI as a staging modality, there is an increasing detection of synchronous primaries of prostate and rectal cancers. Curative treatment of both malignancies requires combining treatment that differ substantially in target volumes and dose prescriptions. Sharing institutional experiences is therefore essential to guide clinical practice in this complex setting Our objective is to describe clinical outcomes of an institutional cohort of patients with synchronous rectal and prostate adenocarcinomas, highlighting the therapeutic
study on QoL among cancer patient. The EORTC QLQ- C30 questionnaire was administered at diagnosis and repeated three months later. Global health status, functional scales (physical, emotional, role, cognitive, and social), and symptom scales were analyzed. Mean scores were compared using paired t-tests, and subgroup analyses were performed by age, gender, residence, education, employment, marital status and tumor type. Results: Global health status significantly improved from baseline to three months (66.7 ± 21.3 vs. 74.8 ± 21.9; p < 0.001). Emotional functioning increased markedly (70.4 ± 28.9 vs. 83.3 ± 25.9; p < 0.001), while other functional domains showed modest non-significant gains. Symptom burden decreased notably for pain, insomnia, dyspnea, and financial difficulties (p < 0.001 for all). Patients aged 61–70 years, those employed, urban residents, and individuals with higher education reported greater QoL improvement (p < 0.001). By tumor group, significant improvements in global health status were observed in gastrointestinal (p = 0.001), genitourinary (p = 0.002), gynecological (p < 0.001), and skin cancers (p = 0.007). Improvements were more pronounced in patients without metastases, those undergoing surgery or curative treatment, and individuals with lower tumor stage. Conclusion: Three months after cancer diagnosis, patients demonstrated a significant improvement in overall and emotional QoL, accompanied by reduced symptom burden and financial distress. These findings suggest an adaptive process following diagnosis and underline the importance of continued psychosocial and supportive care interventions during the initial phase of cancer management. Keywords: quality of life, cancer, symptom burden.
strategies employed. Material/Methods: From 2015 to 2025, seven male patients with histologically confirmed synchronous
adenocarcinomas of the rectum and prostate were identified, including two with synchronous colon primaries. The median age was 76 years (range 70–83). The median Karnofsky Performance Status was 80%. All rectal tumors were cT3a/b and M0, cN+ in six cases.Regarding the prostate tumors, three patients were ISUP grade group 5 (Gleason 4+5), three were ISUP 1, and one was ISUP 2. Two patients had cT3a/b disease, six were cN0, and one had M1b involvement.Treatment consisted of long-course chemoradiation (45–50.4 Gy in 25–28 fractions) with capecitabine plus sequential boost to prostate (70- 76Gy) in five patients, and short-course RT (25 Gy in 5 fractions) in two patients who needed prompt surgery. Radiotherapy included pelvic, rectal tumor, and prostate volumes. Rectal surgery was performed in five cases while two followed a watch-and-wait approach after radiological and pathological complete response. Hormone therapy was prescribed according to risk. Results: After a median follow-up of 50 months (range 5–123), median overall survival was 51,3 months (range 9- 128,5) and disease-free survival was 43 months (range 9-63,7). No patient developed local rectal cancer recurrence. One patient developed pulmonary metastases which were treated surgically followed by adjuvant chemotherapy, with no evidence of disease at the last follow-up. Two patients developed biochemical and local prostate relapse confirmed by biopsy, successfully managed with salvage HT.
Digital Poster 1794
Feasibility of radiotherapy management in synchronous prostate and rectal cancer: institutional experience. Laura M Álvarez 1 , Monica Caro 1 , Luisa M Díaz 1 , Beatriz Gutiérrez 1 , Josep Jové 1 , J Guadalupe Molina 1 , Isabella Vargas 1 , Eva Ortiz 1 , Jefferson S Moreno 1 , Andrea Plaja 2 , Elisabet Momprade 2 , Jose Luis Manzano 2 , Laura Layos 2 , Pol Servian 3 , Marta M Cuadrado 4 , M Carmen Sanchez 5 , Silvia Comas 1
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