S922
Clinical - Mixed sites & palliation
ESTRO 2026
GA using validated screening tools is feasible and correlated significantly with treatment intent, completion and survival. Incorporating GA in oncology practice can guide individualized treatment decisions to optimize outcomes for older adults with cancer. References: 1. Middelburg JG, Middelburg RA, van Zwienen M, Mast ME, Bhawanie A, Jobsen JJ, Rozema T, Maas H, Geijsen ED, van der Leest AH, van den Bongard DH. Impaired geriatric 8 score is associated with worse survival after radiotherapy in older patients with cancer. Clinical Oncology. 2021 Apr 1;33(4):e203-10.2. Fernández- Camacho E, Ferrer-Ramos C, Morilllo-Macías V, Rodríguez-Cordón M, Sánchez-Iglesias Á, Beato- Tortajada I, Francés-Muñoz A, Muelas-Soria R, Piquer- Camañes T, Santafé-Jiménez AI, Aznar-Tortonda V. The impact of frailty screening on radiation treatment modification. Cancers. 2022 Feb 21;14(4):1072. Keywords: Geriatric assessment, Radiation Oncology Digital Poster 4636 Outcomes of the Quad Shot palliative radiotherapy regimen: a retrospective analysis Bartosz Kamil Sobocki 1 , Edmund Naczk 1 , Joanna Kami ń ska 1 , Anna Kowalczyk 1 , Jacek Rutkowski 1 , Ewa Paw ł owska 1 , Kacper Winiarski 2 , Artur Bandura 1 , Ewa Szutowicz 1 , Krzysztof Konopa 1 , Rafa ł Dziadziuszko 1 , Bart ł omiej Tomasik 1,3 1 Oncology and Radiotherapy, Medical University of Gda ń sk, Gda ń sk, Poland. 2 Oncology, Medical University of Gda ń sk, Gda ń sk, Poland. 3 Centre for Experimental Cardiooncology, Medical University of Gda ń sk, Gda ń sk, Poland Purpose/Objective: To retrospectively analyze the single centre experience with the Quad Shot (QS) palliative radiotherapy regimen (14.8 Gy in 4 fractions, delivered twice daily with ≥ 6-hour intervals on two consecutive days, repeated monthly up to a total of 44.4 Gy), delivered using modern intensity-modulated techniques, focusing on safety, treatment response, and survival outcomes. Material/Methods: We retrospectively reviewed all patients treated with QS between 2024 and 2025 (n = 18). Safety was assessed based on clinical documentation and retrospectively graded according to CTCAE v6.0. Per institutional protocol, patients were clinically evaluated before each QS cycle to assess tolerance and eligibility for continuation. Treatment response was evaluated as the change in gross tumor volume (GTV) between baseline imaging before the first QS
survival. Material/Methods:
Patients giving consent were enrolled in the study and evaluated using: Cancer and Aging Research Group (CARG), G8 questionnaire, Groningen Frailty Indicator (GFI), Timed up & go (TUG), and Mini-Cog. Treatment decisions were based on conventional clinical assessment and individual disease and stage standards. Demographic, treatment, adherence, and survival-related data were collected. No specific intervention was introduced based on GA scores. Analysis was done using SPSS v.26. Results: Between April and December 2023, 59 patients (male: female 2:1) with median age 71 years (range: 65-86 years) and median Karnofsky Performance Status (KPS) 80 (range: 50-90) were evaluated. Of these, 23.7% patients had ≥ 2 comorbidities. All enrolled patients completed the administered questionnaires. CARG score suggested low, intermediate, and high risk of treatment toxicity in 34 (57.6%), 21 (35.6%), and 4 (6.8%) patients, respectively. Among the frailty indices – we observed G8 <15 in 25 (42.3%), GFI ≥ 4 in 23 (38.9%), TUG >20 seconds in 11 (18.6%), mini-Cog <4 in 26 (44%), and history of falls in 6 (10.1%) patients; all four scores were abnormal in 11 (18.6%) patients. Table 1 describes the demographic data. Treatment intent being palliative was significantly associated with frailty (GFI, p=0.003), poor performance status (PS ≥ 2, p=0.003), impaired mobility (TUG>20 seconds, p<0.001), abnormal G8 (p=0.025), and high risk CARG (p<0.001). Treatment non-completion correlated significantly with frailty: abnormal GFI, p=0.046), PS ≥ 2 (p=0.004) and abnormal TUG (p=0.012). Change in KPS during treatment was non significantly associated with GA scores. Mortality was found to have a significant correlation with frailty: abnormal GFI (p=0.017), abnormal G8 (p=0.035), and abnormal TUG (p=0.001). Cognitive assessment using mini-COG scores and CARG score did not show independent associations with survival.
Conclusion:
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