S948
Clinical - Non-malignant & functional radiotherapy
ESTRO 2026
days), while 52 had records available after both the initial LDRT and a second series (median 136 days). A significant improvement in VPS was observed between the end of first LDRT and the follow-up visit (Wilcoxon p = 0.0019). In contrast, no statistically significant difference was seen when comparing VPS after first and second LDRT (Wilcoxon p = 0.63), suggesting no additional immediate benefit from repeated treatment. Among all patient and treatment factors analyzed, only the dose regimen was associated with response, favoring the 1 Gy protocol (Chi-squared test,
vestibular schwannoma. Jpn J Clin Oncol. 2013;43(8):805–812. Bowden G, Cavaleri J, Monaco E, et al. Cystic vestibular schwannomas respond best to radiosurgery. Neurosurgery. 2017;81(3):490–497. Keywords: Vestibular schwannoma, Radiosurgery Digital Poster 2741 Retrospective Evaluation of Low-Dose Radiotherapy in Ankle Joint Osteoarthritis Andreas Brack 1 , Georg Herget 2 , Anca-Ligia Grosu 1 , Andreas Rimner 1 1 Department of Radiation Oncology, University Clinic of Freiburg, Freiburg, Germany. 2 Department of Orthopaedics and Trauma Surgery, University Clinic of Freiburg, Freiburg, Germany Purpose/Objective: Low-dose radiotherapy (LDRT) plays an important role in the symptomatic treatment of benign, inflammatory conditions. Due to limited data, current clinical guidelines assign no evidence level to LDRT for ankle OA, which is less common than knee or hip OA but as relevant, mainly affecting younger posttraumatic patients. This retrospective analysis evaluates the clinical benefit of LDRT for pain reduction and function in ankle osteoarthritis, using the Von-Pannewitz-Score (VPS). Material/Methods: All patients receiving LDRT for ankle OA at the University of Freiburg between January 2010 and June 2024 were analyzed. LDRT was performed according to German Society of Radiation Oncology (DEGRO) recommendations (6 x 1Gy (GD 6Gy) or 6 x 0,5Gy (GD 3Gy)). The primary endpoint was improvement of pain symptoms according to the VPS directly after the first LDRT series and at follow-up. Secondary endpoints included VPS directly after the first LDRT compared to after a second LDRT. Patient- and treatment-related factors such age at first LDRT, sex, upper vs lower ankle joint, initial pain severity, pre-LDRT symptom duration, prior posttraumatic osteoarthritis, previous non-LDRT therapeutic interventions, LDRT dose and response to LDRT in other locations were analyzed. Statistical analyses included Wilcoxon signed rank tests, Chi-squared tests, and t-tests. Results: Data from 141 patients with 161 treated ankle joints were included (mean age 69.0 ± 10.0 years; 70.2% women). All patients received either 6 × 1Gy (52.8%) or 6 × 0,5Gy (47.2%). Treatments mainly involved the whole (42.9%) or upper ankle joint (39.7%), with 17.4% at the lower ankle joint. VPS values for initial response after the first LDRT were available for all 161 ankles. Sixty-five ankles had VPS documented both directly after the first LDRT and at follow-up (median 105
p = 0.0119). Conclusion:
A significant symptom improvement was observed between the end of the first LDRT and follow-up. However, repeated LDRT did not provide further immediate symptom relief. References: German Society of Radiation Oncology (DEGRO). S2e Guideline Radiation Therapy of Benign Diseases. Version 3.0, 2022.Valderrabano V, Horisberger M, Russell I, Dougall H, Hintermann B. Etiology of ankle osteoarthritis. Clin Orthop Relat Res. 2009 Jul;467(7):1800-6. doi: 10.1007/s11999-008-0543-6. Epub 2008 Oct 2. PMID: 18830791; PMCID: PMC2690733.Brown TD, Johnston RC, Saltzman CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006 Nov-Dec;20(10):739- 44. doi: 10.1097/01.bot.0000246468.80635.ef. PMID: 17106388. Keywords: Ankle OA, Low Dose RT, Von-Pannewitz- Score Hearing Functional Assessment After Stereotactic Radiosurgery for Vestibular Schwannomas: Four- Year Single-Institution Experience Alice Alves 1,2 , Jorge Moutinho 3 , Fátima Aires 1 , Pedro Soares 1 , Patricia Ferreira 1 , Fernando Costa 1,2 , Daniela Saraiva 1,2 , Rosa Patrício 1 , Anabela Gonçalves 1 , Vitor Silva 4 , Claudia Teixeira 4 , Gabriel Farinha 1 , Rui Tuna 5 , Pedro Alberto Silva 5 , Luisa Sampaio 6 , Ana Rita Figueira 1 , Armanda Monteiro 1 , Ricardo Vaz 3 , Lígia Osório 1 1 Radiation Oncology, São João University Hospital Center, Porto, Portugal. 2 University, University of Vigo, Vigo, Spain. 3 Otorhinolaryngology, São João University Hospital Center, Porto, Portugal. 4 MRI Department, São João University Hospital Center, Porto, Portugal. 5 Neurosurgery Department, São João University Hospital Center, Porto, Portugal. 6 Neuroradiology Department, São João University Hospital Center, Porto, Portugal Digital Poster 2751
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