S961
Clinical - Non-malignant & functional radiotherapy
ESTRO 2026
(25%), and the onset of mild pain (15%) (Figure 1). Regarding the need for analgesic use, we observed a proportional reduction in all groups that received LDRT (Figure 2).
Guckenberger M, Saguner AM, Andratschke N. First magnetic resonance imaging-guided cardiac radioablation of sustained ventricular tachycardia. Radiother Oncol. 2020 Nov;152:203-207. doi: 10.1016/j.radonc.2020.01.008. Epub 2020 Feb 14. PMID: 32067819.Kovacs B, Mayinger M, Schindler M, Steffel J, Andratschke N, Saguner AM. Stereotactic radioablation of ventricular arrhythmias in patients with structural heart disease - A systematic review. Radiother Oncol. 2021. doi: 10.1016/j.radonc.2021.06.036. Epub 2021 Jul 4. PMID: 34233215. Keywords: STereotactic Arrhythmia Radioablation, STAR Digital Poster 5185 Low-Dose radiotherapy for osteoarthritis: a single- institution experience and clinical outcomes. Jorge F Obeso Herrera, Felipe Ospina-Gonzalez, Alba Lopez-Carmona, Elisa F. Salcedo, Carmen Hernandez- Carrillo Martinez-Almeida, Alexandra Hreskova, Jose Medina Suarez, Marta Lloret-Saez-Bravo Radiation Oncology, Dr. Negrin University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain Purpose/Objective Osteoarthritis (OA) is a prevalent degenerative joint condition in which the cartilage is progressively destroyed, causing pain and functional limitation. Physical therapy, pharmacological treatment and surgery are the most used approaches, failing in some cases to provide long-term relief. However, low-dose radiotherapy (LDRT) has become a promising non- invasive treatment option for unresponsive OA pain, resulting from its anti-inflammatory effects. This study evaluates the analgesic and functional outcomes of LDRT in patients with painful osteoarthritis. Material/Methods We analyzed patients who underwent LDRT for OA between 2021 and 2025. Patients were classified by affected side, anatomical region and etiology (Table 1). The total dose delivered was 3 Gy in 6 fractions. Pain intensity and functional outcomes were evaluated using VAS, the use of analgesics and the necessity of reirradiation. The follow-up was conducted before starting the treatment and at one, three, six and 12 months after. Results 34 patients, with osteoarticular pathology in 47 different body parts, were evaluated (Table1). The mean age was 57 years ( 35-90), with a predominance of female (61.76%). The majority of patients rated their pain prior to treatment as severe (75%) or moderate (25%). At one month after completing treatment patients classified pain as severe (50%), moderate
Conclusion LDRT has demonstrated a significant reduction in pain, particularly one month after starting treatment. Alternatively, it may serve as a viable option prior to invasive procedures, as well as assisting patients with high doses of analgesia, comorbidities, and poor disease control. References 1. Koneru, B. N., Sick, J., Shaikh, H. A., Spengler, H., Small, W., Jr, & Shaffer, R. (2025). Low-dose radiation therapy for osteoarthritis: A retrospective single- institution analysis of 69 patients and 168 joints. International Journal of Radiation Oncology, Biology, Physics , 123(2), 352–360. https://doi.org/10.1016/j.ijrobp.2025.04.040
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