Kolling researcher Professor David Hunter and TomButtel who has lived with osteoarthritis for most of his life
Royal North Shore Hospital will help drive one of the world’s largest clinical trials into the effectiveness of stem cell therapy for those with knee osteoarthritis Large-scale trial: stem cell therapy knee osteoarthritis
Kolling researcher Professor David Hunter will lead a two-year study, which will recruit more than 400 participants for the trial sites at RNSH and the Menzies Institute in Hobart. “We will evaluate whether stem cell injections can improve symptoms and slow the progression of the disease in people with mild to moderate knee osteoarthritis,” he said. “Participants will receive three injections over a 12 month period, with researchers to assess levels of pain, physical activity and quality of life throughout the trial.” All participants will receive the same stem cell product, developed from cells from a single, young healthy person. The study follows some small trials which have indicated stem cell therapy may reduce inflammation,
and help the body repair cartilage. David said there was tremendous community interest and many stem cell products available, but to date, there had been no good, rigorous evidence to suggest these products are effective in this context. “It’s really important that we have high-quality trials like this one to produce the evidence that we need around efficacy and safety,” he said. “Osteoarthritis is steadily increasing in prevalence due to our ageing population and the high numbers of people above a healthy weight. “It’s important that we can offer those managing the condition a range of treatment options, on top of the existing conservative approach of
was welcomed by 61-year-old Tom Buttel who has experienced knee osteoarthritis for most of his life after a rugby injury in his teens. “Osteoarthritis has had a big impact on my life, causing considerable pain and limiting quite a few daily tasks,” he said. “I have found, however, that by maintaining my weight and adhering to a personally-tailored exercise program, I’ve been in a much better position to manage my condition. “I’m very excited by the trial and encouraged that it may be an important step towards a safe and effective treatment for people with osteoarthritis.” Further information about the SCUlpTOR study is available at: tinyurl.com/sculptor-trial
weight loss and exercise.” The trial’s announcement
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