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SANZ et al .
TABLE 3 PICOS questions addressed by each Systematic Review Reference Systematic review title
Final PICOS (as written in manuscripts)
Suvan
Subgingival Instrumentation for Treatment of Periodontitis. A Systematic Review.
#1. In patients with periodontitis, what is the efficacy of subgingival instrumentation performed with hand or sonic/ultrasonic instruments in comparison with supragingival instrumentation or prophylaxis in terms of clinical and patient reported outcomes? #2. In patients with periodontitis, what is the efficacy of nonsurgical subgingival instrumentation performed with sonic/ultrasonic instruments compared to subgingival instrumentation performed with hand instruments or compared to the subgingival instrumentation performed with a combination of hand and sonic/ultrasonic instruments in terms of clinical and patient-reported outcomes? #3. In patients with periodontitis, what is the efficacy of full mouth delivery protocols (within 24 hr) in comparison with quadrant or sextant wise delivery of subgingival mechanical instrumentation in terms of clinical and patient-reported outcomes? #1. In patients with untreated periodontitis, does laser application provide adjunctive effects to non-surgical mechanical instrumentation alone? #2. In patients with untreated periodontitis, does application of a PTD provide adjunctive effects to non-surgical mechanical instrumentation alone?
et al. (2019)
Salvi
Adjunctive laser or antimicrobial photodynamic therapy to non-surgical mechanical instrumentation in patients with untreated periodontitis. A systematic review and meta-analysis. The adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo-controlled clinical studies Efficacy of access flaps compared to subgingival debridement or to different access flap approaches in the treatment of periodontitis. A systematic review and meta-analysis. The Efficacy of Pocket Elimination/Reduction Surgery Vs. Access Flap: A Systematic Review Adjunctive effect of systemic antimicrobials in periodontitis therapy. A systematic review and meta-analysis.
et al. (2019)
Donos
In patients with periodontitis, what is the efficacy of adding host modulating agents instead of placebo to NSPT in terms of probing pocket depth (PPD) reduction?
et al. (2019)
Sanz-Sanchez et al. (2020)
#1. In patients with periodontitis (population), how effective are access flaps (intervention) as compared to subgingival debridement (comparison) in attaining PD reduction (primary outcome)? #2. In patients with periodontitis (population), does the type of access flaps (intervention and control) impact PD reduction (primary outcome)? In adult patients with periodontitis after initial non-surgical cause-related therapy and residual PPD of 5 mm or more, what is the efficacy of pocket elimination/reduction surgery in comparison with access flap surgery? In patients with periodontitis, which is the efficacy of adjunctive systemic antimicrobials, in comparison with subgingival debridement plus a placebo, in terms of probing pocket depth (PPD) reduction, in randomized clinical trials with at least 6 months of follow-up. In adult patients with periodontitis, which is the efficacy of adjunctive locally delivered antimicrobials, in comparison with subgingival debridement alone or plus a placebo, in terms of probing pocket depth (PPD) reduction, in randomized clinical trials with at least 6 months of follow-up. #1. Does regenerative surgery of intraosseous defects provide additional clinical benefits measured as Probing Pocket Depth (PPD) reduction, Clinical Attachment Level (CAL) gain, Recession (Rec) and Bone Gain (BG) in periodontitis patients compared with access flap? #2. Is there a difference among regenerative procedures in terms of clinical and radiographic gains in intrabony defects? #1. What is the efficacy of regenerative periodontal surgery in terms of tooth loss, furcation conversion and closure, horizontal clinical attachment level (HCAL) and bone level (HBL) gain as well as other periodontal parameters in teeth affected by periodontitis-related furcation defects, at least 12 months after surgery? #2. NM: to establish a ranking in efficacy of the treatment options and to identify the best surgical technique.
Polak et al. (2020)
Teughels et al. (2020)
Herrera et al. (2020)
Adjunctive effect of locally delivered antimicrobials in periodontitis therapy. A systematic review and meta-analysis.
Nibali
Regenerative surgery versus access flap for the treatment of intra-bony periodontal defects: A systematic review and meta-analysis
et al. (2019)
Jepsen
Regenerative surgical treatment of furcation defects: A systematic review and Bayesian
et al. (2019)
network meta-analysis of randomized clinical trials
(Continues)
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