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HERRERA ET AL .
Overall certainty of the evidence Limited due to the scarcity of the available evidence.
of peri-implant mucositis/incipient peri-implantitis (bone loss less or equal to three threads). Results showed a significant added effect in reducing BOP and PD at 6 months. However, BOP relapsed after 9 months (Renvert et al., 2006).
From evidence to recommendation — additional considerations
Risk of bias Not applicable.
Acceptability Well accepted intervention, although patients may complain for a short time of food entrapment. Feasibility Prosthesis modification should be implemented by general dentists as well as specialist.
Effect sizes and their clinical relevance Not applicable.
Consistency Not applicable.
Ethical considerations Not applicable.
Balance of benefit and harm Harm versus benefit considerations on the use of antibiotics need to be undertaken. The use of antibiotics should always meet the antibi- otic stewardship guideline.
Economic considerations Not applicable.
Overall certainty of the evidence Not applicable.
Legal considerations Not applicable.
From evidence to recommendation — additional considerations
R6.8. In patients with peri-implant mucositis, what is the efficacy of locally administered antibiotics adjunctive to PMPR?
Acceptability Not applicable.
Feasibility Not applicable.
PICOS question addressed by an SR
R6.8: Evidence-based recommendation In patients with peri-implant mucositis, we recommend not to use locally administered antibiotics . Supporting literature (Dommisch et al., 2023; Renvert et al., 2006) Quality of evidence No direct evidence available Grade of recommendation GradeA — ## Strength of consensus Unanimous consensus (0% of the group abstained due to potential CoI)
Ethical considerations The use of antibiotics should always meet the antibiotic stewardship guideline. Economic considerations High economic costs and limited availability of products in European countries need to be considered.
Legal considerations Not applicable.
Background
Intervention
R6.9. In patients with peri-implant mucositis, what is the efficacy of other locally administered agents adjunctive to PMPR?
Professional administration of topical antibiotics, with sustained drug release, following non-surgical mechanical/physical therapy in patients with peri-implant mucositis.
PICOS question addressed by an SR
Available evidence
R6.9: Evidence-based recommendation In patients with peri-implant mucositis, we suggest not to use locally administered agents (antiseptics, ‘ postbiotics ’ , desiccant gel) as adjuncts to PMPR
Number and design of included studies No study could be identified when considering the inclusion criteria out- lined in the SR (Dommisch et al., 2023). However, one RCT ( n = 32) eval- uated the adjunctive effect of minocycline microspheres in the treatment
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