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HERRERA ET AL .
Overall certainty of the evidence Very low.
(Personal). Payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events: Dentsply Implants IH, Spanish Society of Periodontology (SEPA), French Society of Periodontology (Lecture, personal). Support for attending meetings and/or travel: Dentsply Implants IH, Spanish Society of Periodontology (SEPA), French Society of Periodontol- ogy, EFP (Travel support when participating as an invited speaker). Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: National Board of Health and Wel- fare, Sweden (National guidelines in Dentistry) (University institu- tion grant); Swedish Quality Registry for Caries and Periodontal Disease (Personal fee). Iain Chapple (Chair) reports — Grants or contracts from any entity: Grant from GSK (PhD studentship & other grants); Two grants from DEBRA (Epidermolysis Bullosa Charity), one grant from Unilever (Research Grants); NIHR Biomedical Research Centre Grant (Research infrastructure grant). Royalties or licences: Quin- tessence (Book Royalties). Consulting fees: J&J, GSK, Unilever, Philips (Consultancy Fees). Payment or honoraria for lectures, pre- sentations, speakers' bureaus, manuscript writing, or educational events: J&J, GSK, Unilever, Philips (Sponsored Lecture Fees); Lec- tures to Swiss, German, Italian, Portuguese, Turkish, Polish, Danish, Austrian, British societies, IAP Colombia (Expenses paid for meet- ings). Support for attending meetings and/or travel: P&G, J&J (Support to participate in international conference). Patents planned, issued, or pending: 65 patents (Patents on saliva diagnos- tics). Leadership or fiduciary role in other board, society, commit- tee or advocacy group, paid or unpaid: European Workshop Committee of the EFP — co-chair; Invited member of EFP Executive Board (Unpaid); Chair of FDI WG on Oral & Systemic Health (Unpaid); Scientific Advisor to the British Society of Periodontol- ogy Executive Board (Unpaid). Other financial or non-financial interests: non-financial (wife runs Oral Health Innovations, which has the licence for PreViser and DEPPA risk assessment software in theUK). David Herrera (Chair) reports — Grants or contracts from any entity: Dentaid, Kulzer, Lacer, ZIZ Dental, Isdin, Affinity (Research contract via university); University of Bristol, University of Pisa (Research contract via university). Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events: Oral-B, Straumann, Klockner, Dexcel, Dentaid, Colgate, Lacer Spanish Society of Periodontology (SEPA), EFP, Saudi Society of Peri- odontology (SSP), Ukrainian Association of Periodontology (UAPerio), Iberopanamerican Federation of Periodontology (FIPP), Dansk Parodontologisk Selskab (DPS) (Personal honoraria for lec- tures); Dentaid (Manuscript writing). Support for attending meet- ings and/or travel: Oral-B, Straumann, Klockner, Dexcel, Dentaid, Colgate (Support for attending conferences and/or travel when participating as invited speaker). Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: Patron of the Fundaci on SEPA de Periodoncia e Implantes Dentales (Unpaid); Chair of the European Workshop Committee of the EFP
From evidence to recommendation — additional considerations
Acceptability Not applicable.
Feasibility Related products may not be available in all European countries.
Ethical considerations Harms related to the intake of local antibiotics must be balanced with potential benefits.
Economic considerations Additional costs related to the medical product must be considered.
Legal considerations Not applicable.
AUTHOR CONTRIBUTIONS David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple, Søren Jepsen, Anton Sculean, Moritz Kebschull, Panos N. Papapanou, Maurizio S. Tonetti, Mariano Sanz and the methodological consul- tant (Ina Kopp) substantially contributed to the conception and design of the project, to the interpretation of data, and to the draft- ing and critical review of the manuscript. The EFP workshop partici- pants (listed previously) significantly contributed by critically reviewing the guideline document and by participating in the work- shop discussions. All authors approved the final version of the manuscript. ACKNOWLEDGEMENTS The authors express their gratitude to all reviewers involved in the preparation of the SRs and sincerely thank those organizations that participated in the guideline development process: Council of European Dentists, European Dental Hygienists Federation, European Dental Students' Association, European Society for Endodontology, Platform for Better Oral Health in Europe. CONFLICT OF INTEREST STATEMENT Individual potential conflict of interest forms were completed by all participants and are available on file at the EFP and extracted in the Supporting Information, available online. Potential conflicts of interest in the previous 36 months, reported by the chairs of the workshop (in alphabetic order) are listed here: Tord Berglundh (Chair) reports — Grants or contracts from any entity: Dentsply Implants IH, Osteology Foundation (University institution grants). Consulting fees: Dentsply Implants IH
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