Riley Children's Health Annual Report 2022 – 2023

Home to a high-volume, nationally ranked pediatric cardiology program, Riley Children’s Health delivers the full continuum of cardiac care from fetuses and premature infants to adults with congenital heart disease. Achieving exceptional patient outcomes, the Riley Heart Center has experienced significant growth in recent years. In addition to offering specialists in every clinical area of cardiology, we are active in research to address unmet needs in pediatric cardiology. CARDIOLOGY

Specialized programs Fetal Cardiology Program

Partners in the Fetal Center, our cardiologists offer in- depth diagnostic imaging, evaluation and consultation during pregnancy to develop a comprehensive treatment plan. Cardiovascular Genetics Program Fully integrated CV genetics program provides testing, evaluation and consultation for the full spectrum of heritable heart conditions: ■ Aortopathy ■ Cardiomyopathy ■ Inherited arrhythmia ■ Pulmonary hypertension ■ Familial lipid disorders ■ Congenital heart disease/ syndromes Home Monitoring Program ■ Home monitoring has expanded beyond single ventricle to heart failure patients (2021) and to ventricular assist device and post-heart transplant patients (2022) ■ Monitored 29 babies in 2022 ■ 0% mortality after discharge for single ventricle home monitoring population since 2016 *** Hospital Discharge Virtual Follow-up and Management Program The Riley Heart Center’s innovative advanced practice provider-led virtual care model improves access, minimizes readmission and addresses barriers to care.

DIVISION CHIEF Larry W. Markham, MD, FAAP, FACC Phillip Murray Professor of Pediatric Cardiology; Professor, Departments of Pediatrics and Medicine, IU School of Medicine > Connect with Dr. Markham on Doximity. >

Program distinctions


■ Ranked among the leading pediatric heart programs in the nation by U.S. News & World Report

■ Part of the Cardiac Developmental Biology group in the IU School of Medicine Herman B Wells Center for Pediatric Research

■ TOMORROW clinical trial for children with pulmonary arterial hypertension

26 board certified physicians


■ National leader in patient outcomes with mortality rates below benchmark *

See full team member list

National program affiliations and accreditations ■ Intersocietal Accreditation Commission ■ Cardiac Neurodevelopmental Outcome Collaborative ■ Adult Congenital Heart Association ■ Pulmonary Hypertension Center of Comprehensive Care ■ Engineering in Medicine Institute pilot program to study myofibroblasts in dystrophin-deficient cardiac disease progression ■ U.S. Department of Defense-funded study ** to define cell populations and cell type-specific transcriptional dysregulation in pediatric coarctation of the aorta


■ Integrated care model with subspecialty care coordination and novel approaches

to cardiac intensive care, inpatient navigation and home monitoring

Journal of the American Heart Association: October 2022

Learning to Crawl: Determining the Role of Genetic Abnormalities on Postoperative Outcomes in Congenital Heart Disease Progress in Pediatric Cardiology: April 2022 The Successful Use of Verapamil in Infants with Fascicular Ventricular Tachycardia Circulation, Cardiovascular Quality and Outcomes: December 2022 Perioperative Considerations for Pediatric Patients with Congenital Heart Disease Presenting for Noncardiac Procedures: A Scientific Statement from the American Heart Association Cardiology in the Young: July 2022 Utilizing Technology to Expand Home Monitoring to High-Risk Infants with CHD

■ Only formalized comprehensive adult congenital heart disease program in Indiana; program accredited by the Adult Congenital Heart Association

2021 539 visits completed

2022 625 visits completed

Mean timing of virtual visit: 2.8 days after hospital discharge

Significant issues addressed: Neonatal feeding concerns, additional education about upcoming surgery, medications, prognosis, symptom management, ordering interval testing and arranging for home equipment Results: ■ Appropriate escalation of care, potentially preventing patient harm ■ Synchronized visits with support services (dietary, social work, pharmacy) ■ Added convenience for patient families

Fetal Echocardiogram Volume: 2018 – 2022

Echocardiogram Interpretations: 2018 – 2022 Our program serves more than 40 Indiana hospitals and is achieving record volumes.

Performed at nine locations across Indiana.





17,362 17,938 17,887


1,647 1,670

39 research publications in 2022











*** As of Dec. 31, 2022

* Source: The Society of Thoracic Surgeons (STS) Table 16, Harvest Report, published January 2023 for period ending June 30, 2022 ** The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD, 21702-5014, is the awarding and administering acquisition office. This work was supported by The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, in the amount of $317,000, through the Peer Reviewed Medical Research Program under Award Number HT9425-23-1-0009. Opinions, interpretations, conclusions and recommendations contained herein are those of the author(s) and are not necessarily endorsed by the Department of Defense.

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Annual Report 2022 – 2023


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