CancerInstituteReport_2022

Bettie and Oscar Bragg Cancer Research Endowment

PI: Laura Enomoto, MD, Assistant Professor, Department of Surgery Title: Al-Enabled Robot for Genetic Risk Assessment Education in Colorectal Cancer Patients: A Pilot Study Grant Award: $40,000 PI: Joseph Jackson, PhD, Assistant Professor, Department of Medicine Title: Treatment of murine GBM using an oncolytic HSV engineered to improve immunogenic tumor destruction Grant Award: $40,000 PI: Kristopher Kimball, MD, Associate Professor, Department of Obstetrics and Gynecology Title: Clinical Recommendations for Adult HPV Vaccination: Exploring Patient and Provider Perspectives Grant Award: $40,000 PI: Jillian Lloyd, MD, MPH, Assistant Professor, Department of Surgery Title: Understanding the negative impact of adverse childhood experiences (ACEs) on breast cancer treatment complications: exploring mechanisms and moderators to inform future interventions for high- risk breast cancer patients Grant Award: $20,000 PI: Ashton Brooks, MD, Assistant Professor, Department of Surgery Title: The Impact of Patient Education and Pain Management Pathways on Opioid Utilization and Patient Reported Outcomes for

PI: John L. Bell, MD, Professor, Department of Surgery and Director, UTMC Cancer Institute Title: TARGET - healTh Assessment pRoGram via mobilE ouTreach Grant Award: $40,000 PI: Stefanos Boukovalas, MD, Assistant Director, Department of Surgery/Division of Plastic and Reconstructive Surgery Title: The Impact of Comprehensive Lymphedema Treatment on Clinical Outcomes, Quality of Life and Financial Toxicity: A Prospective Study in Diverse Oncologic Population. Grant Award: $26,500 PI: Jonathan Boone, MD, Assistant Professor, Gynecologic Oncology, Department of Obstetrics and Gynecology Title: Use of a Fasting Mimicking Diet in Patients Undergoing Chemotherapy for Gynecologic Malignancies Grant Award: $27,200

Cancer Institute Endowment Grant Awards Funding Year 2022 Cycle 3 PI: Larry Kilgore, MD, Professor and Chairman, Department of Obstetrics and Gynecology, Division Director, University Gynecologic Oncology Title: Dysregulation of whole-body metabolism in ovarian cancer Grant Award: $40,045 PI: Joseph Jackson, PhD, Assistant Professor, Department of Medicine Title: Induction of Anti- Glioblastoma Tumor Immunity Using Oncolytic HSV Grant Award: $40,000 PI: Gregory Low, MD, Assistant Professor, Department of Surgery Title: Utility of personalized cell- free circulating tumor DNA assay for identification of response to total

In 2015, under the leadership of Becky and Steve South, an initiative to create our first cancer research endowment began. This impactful initiative culminated with the medical center’s “An Evening in Orange” event on April 16, 2016. Now named the Bettie and Oscar Bragg Cancer Research Endowment, and through the generosity of hundreds of donors, more than $5 million was given toward this impactful initiative. We are truly grateful to the generous donors for their investment in cancer research on our campus. The Bragg Cancer Research Endowment (CRE) funds meaningful cancer research on the campus of the medical center and the UT Graduate School of Medicine. The first funds from the CRE became available for distribution in 2020, following an application and peer- reviewed process. Three research grants were awarded in 2020 and since then, 18 grants totaling $561,953 have been funded (see accompanying list of grantees).

Cancer Research Endowment Grant Awards Funding Year 2020 Cycle 1 PI: Jillian Lloyd, MD, MPH, FACS, Assistant Professor, Department of Surgery, Division of Surgical Oncology Title: An Interdisciplinary Approach to Reducing Health Disparities for Low-Income Appalachian Women with Estrogen-Positive Breast Cancer Grant Award: $40,000 PI: Laurentia Nodit, MD, Professor, Department of Pathology Title: Oral microbiome changes in cancer therapy-induced oral

neoadjuvant therapy Grant Award: $38,316

PI: Dustin Osborne, BS, MS, PhD, Associate Professor, Department of Radiology Title: Radiolabeled fluconazole for differentiation of fungal infection

PI: Eric R. Carlson, DMD, MD, EdD, FACS, Professor and

mucositis: a pilot study Grant Award: $40,000

Kelly L. Krahwinkel Endowed Chair, Department of Oral and Maxillofacial Surgery Title: Characterizing a Unique Mechanism as a Potential Therapeutic Agent in Head and Neck Squamous Cell Carcinoma Using Metformin Grant Award: $20,000 PI: Dustin Osborne, BS, MS, PhD, Associate Professor, Department of Radiology Title: Pilot Study to Determine PET/ CT Extravasation Patient Impact and Patient Rescan Criteria Grant Award: $20,000

PI: Larry C. Kilgore, MD, Professor and Chairman, Department of Obstetrics and Gynecology, Division Director, University Gynecologic Oncology Title: Developing a Coordinated Model to Increase HPV Vaccine Education, Recommendations and Uptake Grant Award: $20,000

from malignant disease Grant Award: $9,902

Total: 128,263

Cancer Institute Endowment Grant Awards Funding Year 2023 Cycle 4 PI: Manasi Balachandran, PhD Title: Development of Novel Chimeric Antigen Receptor Macrophages (CAR-M) for Light

Breast Surgery Patients Grant Award: $20,000

To support the work of the researchers and make a gift to the CRE, please scan the QR code.

Total: $100,000

Total: 200,000

Cancer Research Endowment Grant Awards Funding Year 2021 Cycle 2

Chain Amyloid Clearance Grant Award: $40,000

Total: $133,700

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