QUARTERLY BEAT / DECEMBER 2024
QUARTERLY BEAT / DECEMBER 2024
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SCIENTIFIC ADVANCEMENTS POINT TO A PROMISING FUTURE There have been many recent advancements for urinary tract health that are providing new diagnostics, genetic insights and other research regarding diets to prevent uroliths in animals. Ongoing research continues to investigate the connection between cystine stones in intact male dogs, 3,12 urinary microbiome and its role in struvite and CaOx formation, 13,14 and the gut-urinary axis. As procedures and techniques continue to advance, there are minimally invasive techniques and surgeries for improved stone removal.
It’s time to switch to a 503B facility like Epicur Pharma. Having trouble getting compounded medications and experiencing shortened beyond-use dates?
Understanding the unique aspects of struvite and CaOx stones allows us to tailor prevention strategies more effectively. By emphasizing hydration, tailored diets for urolith prevention that also address other comorbidities and risk factors, and regular monitoring, we can improve patient outcomes and minimize stone recurrence. Each animal is unique, so individualized approaches are crucial. By staying informed about the latest research and working with other veterinarians, we can optimize animal care and improve health outcomes.
503B outsourcing facilities like Epicur Pharma are not affected by new GFI #256 requirements or new USP guidelines. Learn more about what these new guidelines mean for you and your practice at epicurpharma.com/usp-guidelines
REFERENCES
1. Albasan H, Lulich JP, Osborne CA, et al. Effects of storage time and temperature on pH, specific gravity, and crystal formation in urine samples from dogs and cats. J Am Vet Med Assoc 2003;222:176-179. 2. Dear JD, Shiraki R, Ruby AL, et al. Feline urate urolithiasis: a retrospective study of 159 cases. J Feline Med Surg 2011. 3. Kopecny L, Palm CA, Segev G, et al. Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006-2018). J Vet Intern Med 2021;35:1406-1415. 4. Kopecny L, Palm CA, Segev G, et al. Urolithiasis in cats: Evaluation of trends in urolith composition and risk factors (2005-2018). J Vet Intern Med 2021;35:1397-1405. 5. Furrow E, Patterson EE, Armstrong PJ, et al. Fasting Urinary Calcium- to-Creatinine and Oxalate-to-Creatinine Ratios in Dogs with Calcium Oxalate Urolithiasis and Breed-Matched Controls. J Vet Intern Med 2015;29:113-119. 6. Paßlack N, Zentek J, Larsen JA, et al. Impact of hyperlipidaemia on intermediary metabolism, faecal microbial metabolites and urinary characteristics of lipoprotein lipase deficient vs. normal cats. J Anim Physiol Anim Nutr (Berl) 2018;102:e139-e146. 7. Paulin MV, Dunn M, Vachon C, et al. Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs. J Vet Intern Med 2022;36:146-155.
8. Kennedy SM, Lulich JP, Ritt MG, et al. Comparison of body condition score and urinalysis variables between dogs with and without calcium oxalate uroliths. J Am Vet Med Assoc 2016;249:1274-1280. 9. Lulich JP, Berent AC, Adams LG, et al. ACVIM Small Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats. J Vet Intern Med 2016;30:1564-1574. 10. Torres-Henderson C, Bunkers J, Contreras ET, et al. Use of Purina Pro Plan Veterinary Diet UR Urinary St/Ox to Dissolve Struvite Cystoliths. Top Companion Anim Med 2017;32:49-54. 11. Dear JD, Larsen JA, Bannasch M, et al. Evaluation of a dry therapeutic urinary diet and concurrent administration of antimicrobials for struvite cystolith dissolution in dogs. BMC Vet Res 2019;15:273. 12. Larsen JA, Hulsebosch S, Henthorn PS, et al. Urinary cystine/ creatinine concentrations in dogs with suspected androgen- dependent cystine urolithiasis before and after castration. In: ACVIM research abstract, Minneapolis, MN 2024. 13. Coffey EL, Gomez AM, Burton EN, et al. Characterization of the urogenital microbiome in Miniature Schnauzers with and without calcium oxalate urolithiasis. J Vet Intern Med 2022;36:1341-1352. 14. Coffey EL, Gomez AM, Ericsson AC, et al. The impact of urine collection method on canine urinary microbiota detection: a cross- sectional study. BMC Microbiology 2023;23:101.
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