Authored by Dr Kirk Sanford. At Longevity Medical Institute, we offer the most advanced regenerative medical technologies available, including our TriFusion Therapy, combining three powerful integrated modalities: Extracorporeal Blood Oxygenation and Ozonation (EBOO), Full Spectrum Ultraviolet Blood Irradiation (UVBI), and LED Blood Irradiation (LED-BI).
TriFusion Ozone Therapy (03/UV/LED) Advanced Regenerative Ozone Therapy at Longevity Medical Institute
How the TriFusion System (O3/UV/LED) Works
Step 7: TriFusion Process Complete
Step 6: LED Light (Photobiomodulation)
Step 5: Ultraviolet (UV) Irradiation
Step 1: Extraction
TriFusion Device
Step 3: Ozonation (O3 Infusion)
Step 8: Systemic E ects and Integration Completed
Step 2: EBOO Filter
Step 4: Ozonation Complete
Overview At Longevity Medical Institute, we offer the most advanced regenerative medical technologies available, including our TriFusion Ozone Therapy, combining three powerful integrated modalities: Ozone, Multi-Spectrum UV, and LED Photobiomodulation light. This unique approach detoxifies, oxygenates, and rejuvenates while delivering photobiological stimulation to the immune and circulatory systems. The result is a therapy that may activate healing at the cellular level—enhancing mitochondrial function, reducing inflammation, eliminating pathogens, and supporting immune resilience. Watch Video
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How the Treatment Works
Extraction Step 1:
EBOO Filter Step 2:
This step removes toxic byproducts, excess cytokines, cellular debris, lipid peroxides, and other inflammatory mediators while preserving beneficial components of the blood.
Ozonation (O Infusion) Step 3:
Ozone interacts with blood components to:
Break down pathogens (bacteria, viruses, fungi). Enhance red blood cell flexibility and oxygen-releasing capacity. Activate antioxidant defenses by stimulating Nrf2 pathways. Trigger immune modulation through mild oxidative signaling.
Ozonation Completed Step 4:
Ultraviolet (UV) Irradiation Step 5:
The ozonated and oxygenated then passes through a UV light chamber, utilizing UV-A and UV-B wavelengths.
UV exposure helps:
Destroy pathogens Enhance immune recognition of abnormal or infected cells.
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Oxidize toxins and activate white blood cells for enhanced systemic immune response. Improve microcirculation and reduce hypercoagulability.
LED Light Therapy (Photobiomodulation) Step 6:
At the same time of UV exposure, their is LED lights emitting specific wavelenghts (eg red, blue, green, and infrared).
This step helps to promote:
Mitochondrial activation in white and red blood cells (via cytochrome c oxidase stimulation). Reduction in oxidative stress and inflammation. Vascular relaxation and improved nitric oxide (NO) signaling. Photobiomodulation benefits at the cellular level, supporting regeneration and detoxification.
All Three Modalities are Now Complete Step 7:
This process typically takes 45–60 minutes per session.
Systemic Effects and Integration Step 8:
Improved oxygen delivery to tissues. Decreased inflammation and pain. Immune balancing (downregulating autoimmunity or upregulating suppression of infections). Enhanced detoxification capacity at the liver and cellular levels. Mitochondrial support and rejuvenation, which may assist in chronic fatigue, infections, vascular issues, and neurodegeneration.
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Mechanisms of Ozone
Triggers hormetic oxidative stress that activates Nrf2, a transcription factor that boosts antioxidant defenses and detoxification pathways.
Modulates immune signaling through lipid ozonation products (LOPs) and indirect stimulation of cytokines.
Enhances mitochondrial function, leading to better ATP production.
Kills microbes in the extracorporeal loop through direct oxidation.
02 Ultraviolet Irradiation (UVI)
Mechanisms of UV Light
Direct inactivation of microbes via DNA/RNA disruption (especially UVC).
Induces hormetic response that boosts antioxidant enzymes.
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Modulates immune function through toll-like receptor activation and nitric oxide (NO) upregulation.
Photobiomodulation stimulates tissue repair and inflammation resolution.
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Visible Light LED Benefits
Full-spectrum LED strips stimulate additional photobiological effects:
Red and infrared: Enhance mitochondrial health and circulation Blue and violet: Antimicrobial and anti-inflammatory properties Green and yellow: Skin and tissue rejuvenation
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Conditions Supported
Neurological & Cognitive Alzheimer’s, Parkinson’s, MS, ALS, neuropathies, migraines, TBI, post-stroke, Long COVID, brain fog
Autoimmune & Inflammatory Rheumatoid arthritis, lupus, Hashimoto’s, IBD, fibromyalgia, chronic inflammatory syndromes
Infectious & Toxic Load Chronic viral infections (EBV, CMV, HSV, HPV), Lyme disease, mold toxicity, heavy metal toxicity, CIRS
Cardiovascular & Metabolic Atherosclerosis, hypertension, diabetes, wound healing issues, metabolic syndrome
Musculoskeletal & Pain Syndromes Osteoarthritis, tendonitis, bursitis, back and neck pain, post-surgical inflammation
Longevity & Optimization Mitochondrial support, immune tuning, detoxification, performance recovery, biohacking, anti-aging
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What to Expect During Therapy
Before Your Session Eat a balanced meal with protein and healthy fats Stay well hydrated to enhance vein access and therapeutic outcomes
During Your Session You’ll relax comfortably while your blood is withdrawn, ozonated, illuminated, and returned simultaneously
After Your Session No downtime—resume normal activities immediately
You may feel energized, relaxed, or experience detox-like fatigue—responses vary Results are cumulative; benefits increase over time with consistent application
Treatment Frequency at Longevity Medical Institute
Each protocol is personalized based on your condition, diagnostic markers, and treatment response. However, the following guidelines provide a foundational framework:
Chronic Illness, Neurological Disorders, Auto-Immune Conditions, or General Immune Dysregulation 1 session per week for 3–5 weeks Progress is reevaluated based on labs and symptom improvement Optional Maintenance: 1 session every 4–6 weeks
Wellness, Longevity & Performance 1-4 sessions annually Ideal for detoxification, mitochondrial support, recovery, and ongoing optimization
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These frequencies may be adjusted depending on progress, symptom resolution, and individual goals. Safety and Contraindications Acute Immune Recovery 1–2 sessions over a 1–2 week period Beneficial for rapid immune support following infections or inflammatory stressors EBOO 03UV is extremely well-tolerated when administered by trained professionals. At Longevity Medical Institute, we perform full clinical evaluations to ensure safety and efficacy.
Contraindications
G6PD deficiency Uncontrolled hyperthyroidism Seizure disorders Severe cardiovascular instability Thrombocytopenia Porphyria (specific to UV light sensitivity)
Optional biomarker panels measured in the in-house LMI Clinical Lab (e.g., CRP, oxidative stress markers, immune panels) may be used to track progress.
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EBOO Full Spectrum UV reflects our belief that true healing occurs at the cellular level. As leaders in regenerative and anti-aging medicine, we integrate this therapy as a core part of our advanced treatment protocols, often alongside: Why We Offer TriFusion at LMI
Stem Cells and Exosomes Peptide therapies IV nutrient drips Hyperbaric oxygen therapy (HBOT) Longevity Recharge Station: 10 wave length PBM light, molecular hydrogen inhalation, and more Clinical lab diagnostics
Whether you're facing chronic illness or simply want to feel and function at your peak, TriFusion is a cornerstone in our personalized care ecosystem.
Contact Longevity Medical Institute to learn more about how personalized TriFusion therapy can help you stay at your peak for years to come.
Paseo Malecon San Jose 137, Zona Hotelera, 23405 San José del Cabo, B.C.S., Mexico Call or SMS (US & Canada): 1-833-LMI-CABO WhatsApp International: +52 624 237 1594 Visit: longevity-institute.com Contact Us
Book Free Consultation
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Important Disclosure In San Jose del Cabo (B.C.S), Mexico, where we conduct these treatments, our clinic operates under the regulatory oversight of COFEPRIS (Comisión Federal para la Protección contra Riesgos Sanitarios), which is Mexico's equivalent of the U.S. Food and Drug Administration (FDA). COFEPRIS ensures the safety, efficacy, and quality of medical treatments and healthcare practices. Our clinic is licensed by COFEPRIS, guaranteeing that our treatments meet the highest standards of safety and efficacy. While our stem cell and other therapies are approved by COFEPRIS, they are not approved by the U.S. Food and Drug Administration (FDA). Patients considering these treatments should be aware of this distinction. As with any medical treatment, there are risks involved, and individual outcomes may vary. It is important to consult with your physician, thoroughly research the therapies, and carefully consider these risks before undergoing any stem cell or regenerative therapy. Disclaimer The information provided on this site is for informational purposes only and should not be considered medical advice. This site is not intended for the promotion or solicitation of services to audiences where such promotion may conflict with local regulations, including the United States and Canada. If you have questions or concerns about your health, please consult a qualified healthcare professional. All therapies and treatments discussed are subject to applicable laws and regulations and may not be available in all regions. We encourage all patients to conduct their own research, consult with their healthcare providers, and make informed decisions based on the best available information.
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