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TEZSPIRE is an add-on maintenance treatment for people aged 12 and older with severe asthma. TEZSPIRE is not a rescue medication.

TEZSPIRE can help reduce asthma attacks. So you can be you, no matter who you are.

TEZSPIRE works by reducing inflammation brought on by your body’s overreaction to triggers, and can mean:

Improved asthma symptom control

Fewer asthma attacks

Better breathing and improved lung function

Results may vary. TEZSPIRE is not a rescue medication. The mechanism of action is not fully understood.

ASK YOUR DOCTOR ABOUT TEZSPIRE TEZSPIRE.COM Please see Brief Summary of full Prescribing Information, including Patient Information on adjacent page.

Please see Important Safety Information below.

IMPORTANT SAFETY INFORMATION Do not use TEZSPIRE if you are allergic to tezepelumab-ekko or any of its ingredients. Do not use to treat sudden breathing problems. TEZSPIRE may cause serious side effects, including: • severe allergic (hypersensitivity) reactions, such as rash or eye allergy. Call your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction: o rash o breathing problems o hives o red, itchy, swollen, or inflamed eyes Before using TEZSPIRE, tell your healthcare provider about all of your medical conditions, including if you: • have ever had a severe allergic reaction. • have a parasitic (helminth) infection.

APPROVED USE • TEZSPIRE is a prescription medicine used with other asthma medicines for the maintenance treatment of severe asthma in people 12 years of age and older whose asthma is not controlled with their current asthma medicine. • TEZSPIRE helps prevent severe asthma attacks (exacerbations) and can improve your breathing. • TEZSPIRE is not used to treat sudden breathing problems. Tell your healthcare provider if your asthma does not get better or if it gets worse after you start treatment with TEZSPIRE. • It is not known if TEZSPIRE is safe and effective in children under 12 years of age. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

• have recently received or are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with TEZSPIRE. • are pregnant or plan to become pregnant. • are breastfeeding or plan to breastfeed. It is not known if TEZSPIRE passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use TEZSPIRE. • are taking prescription and over- the-counter medicines, vitamins, or herbal supplements. Do not change or stop taking your other asthma medicines unless instructed to do so by your healthcare provider. The most common side effects of TEZSPIRE include: Sore throat, joint and back pain. These are not all the possible side effects.

TEZSPIRE is a trademark of Amgen Inc. and AstraZeneca. ©2022 AstraZeneca. All rights reserved. US-61893 4/22

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