HudsonAlpha Research Report 2021-2022

SCIENTIFIC ADVISORY BOARD The authority for maintaining the Institute’s founding purpose and determining all other scientific matters is vested in the HudsonAlpha Scientific Advisory Board. A world-class research institute must have a world-class Scientific Advisory Board. Eight uniquely skilled and internationally known investigators have agreed to serve in this capacity. SIOBHAN BRADY, PHD Professor in the Department of Plant Biology and the Genome Center at the University of California, Davis and a Howard Hughes Medical Institute Faculty Research Scholar. SCOTT JACKSON, PHD Genetic Pipeline Design Lead at Bayer Crop Sci- ence. He received his M.S. and Ph.D. degrees from the University of Wisconsin-Madison followed by a fellowship at the University of Minnesota. SHARON PLON, MD, PHD A board-certified medical geneticist and a longstand- ing researcher in the areas of cancer genetics. Plan founded the Cancer Genetics Clinic in 1995 and is Director of the Texas Children’s Cancer Genetics and Genomics Program. VAL SHEFFIELD, MD, PHD Director of medical genetics for the University of Iowa and a faculty investigator at the Howard Hughes Medical Institute. RICHARD SPRITZ, MD Founder and Director of the Human Medical Genetics and Genomics Program at the University of Colorado School of Medicine. LOUISA STARK, PHD Professor of Human Genetics and director of the Genetic Science Learning Center. BARBARA WOLD, PHD Bren professor of molecular biology and director of the Beckman Institute at Caltech.

BRUCE KORF, MD, PHD , is a professor in the Department of Genetics at the University of Alabama at Birming- ham and the chief genomics officer of UAB Medicine. He also is co-director of the UAB-HudsonAlpha Center for Genomic Medicine. Korf is the past pres- ident of the Association of Professors of Human and Medical Genetics and the American College of Medical Genetics

and Genomics and currently is president of the ACMG Foundation for Genetic and Genomic Medicine. He completed his undergrad- uate studies and MD at Cornell University and received his PhD in genetics and cell biology from Rockefeller University. He then did training in pediatrics, child neurology, and genetics at Children’s Hospital, Boston, and is board certified in all three areas, as well as clinical cytogenetics and clinical molecular genetics. His research focus is the genetics and treatment of neurofibromatosis type 1, and he also has a major interest in genetics and genomics education and the integration of genetics into medical practice.

XU WANG, PHD , is an assistant professor in the Department of Pathobi- ology at Auburn University, focusing on comparative genomics of animal health. His research investigates the genetic and epigenetic regulation of gene ex- pression in vertebrates and insects with a focus on allelic imbalance. Alterations of allelic imbalance are often associated

with human and animal diseases, including cancer, imprinting syndromes, aging, and hypertensive disorders during pregnancy, such as pre-eclampsia. The Wang Lab is working to understand the origin, evolution, and mechanism of allelic imbalance and predict how aberrant patterns of allelic imbalance are associated with disorders in humans and other animals.

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