Published evidence for MaiLi
Journal of Clinical and Cosmetic Dermatology ISSN 2576-2826 | Open Access
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This article present the efficacy and safety data from a four-centre pilot study for MaiLi Precise in correcting fine-line wrinkles of the perioral area.
RESEARCH ARTICLE Safety and Efficacy of Using MaiLi® Precise by Mean of Intradermal Injections for Correcting Perioral Fine Lines Paloma Borregón 1 , Juan Caicedo 2 , Raphaëlle Glacet 3, *, Erick Santaella 4 , and Franco Vercesi 5 1 Clínica Kalosia, Madrid, Spain 2 Cclinics, Valencia, Spain 3 Cremer Consulting, Strasbourg, France 4 ERSA Medical & Aesthetics, Monterrey, Mexico 5 Centro Medico Galeno, Milan, Italy Volume 7 - Issue 2 *Corresponding author: Raphaëlle Glacet, Cremer Consulting, 14 rue Sleidan, FR-67000 Strasbourg, France, Tel: +33 (0)3 88 35 14 72; E-mail: gmc@cremerconsulting.com
Received: 14 Dec, 2023 | Accepted: 21 Dec, 2023 | Published: 27 Dec, 2023
Citation: Borregón P, Caicedo J, Glacet R, Santaella E, Vercesi F (2023) Safety and Efficacy of Using MaiLi® Precise by Mean of Intradermal Injections for Correcting Perioral Fine Lines. J Clin Cosmet Dermatol 7(2): dx.doi.org/10.16966/2576-2826.178 Copyright: ©2023 Borregón P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Introduction: Over the last twenty years, dermal fillers have become the backbone for rejuvenating the perioral area, which is one of the most difficult areas to treat. Due to the development of highly sophisticated fillers with radically different rheological properties and innovating techniques, it has become possible to correct specific regions with more natural results than before. This four-center pilot study sought to investigate the efficacy and safety of MaiLi® Precise in correcting fine-line wrinkles of the perioral area. Material and Methods: MaiLi® Precise is a recently introduced Hyaluronic Acid (HA) filler, harnessing the OxiFree ™ technology, for suppleness, flexibility, and high longevity. These properties were deemed particularly suitable for correcting fine-line perioral wrinkles. All injections were performed using intradermal injections, with the fluid HA injected in a very superficial manner, resulting in the formation of very small papules at the wrinkle, disappearing within 1-2 hours. Follow-up occurred at one (T1) and three months (T2) post-injection. Treatment effectiveness was evaluated using the Global Aesthetic Improvement Scale (GAIS), as was the satisfaction of the subjects and investigators. Adverse Events (AEs) were also reported. Results: Overall, 20 patients aged 56 years on average, from four centers, were injected MaiLi® Precise into the perioral area to correct perioral lines using intradermal injections. No specific safety concerns were detected, given that AEs remained mild, were almost all resolved by T1, and were completely absent by T2. Patient and physician satisfaction were both >90% during follow-up. All physicians attributed improved, much improved, or very much improved GAIS scores at T1 and T2, indicating a marked improvement in appearance after injection. Conclusion: Based on the current study results, MaiLi® Precise was shown to be safe and provided satisfactory results from both the patient and the physician’s points of view during a 3-month follow-up. Keywords: Hyaluronic acid; Perioral area; Skin rejuvenation; OxiFree™ technology; MaiLi® filler, Fine lines; Intradermal injection
Borregón P, et al. J Clin Cosmet Dermatol 2023;7(2): doi.org/10.16966/ 2576-2826.178
Introduction The perioral region refers to the lower one-third of the face, which comprises the upper and lower lips, the cheek-lip grooves or nasolabial folds, and the chin. Ageing signs at this region are among the key reasons for patients seeking treatment [1]. Indeed, this region undergoes significant changes during ageing that likely contribute to a “displeased” or “sad” expression [2]. These changes include fine wrinkling around the lips, deep nasolabial and mentolabial folds, elongation and flattening of the upper lip, downturned corners of the mouth, marionette lines, as well as chin irregularities. The perioral region is the most concerned area for facial rejuvenation. Different options exist, Hyaluronic Acids (HAs) being commonly
used [3]. Since 1998, revolumization of facial structures using HA dermal fillers has been instrumental in reducing signs of ageing and increasing attractiveness [4-6]. In the following years, many different HA filler brands and formulations were manufactured, with differing viscoelastic properties [7,8]. Lidocaine was added to certain gels to increase patient compliance [9]. This perioral region remains one of the most difficult areas to treat, owing to its highly dynamic nature. Wrinkles within the cutaneous lip areas range from fine, almost imperceptible lines to multiple deep etchings, generally referred to as barcodes. Previous attempts of correcting these areas with fillers showed that subcutaneous ridges or overcorrection may be generated in relation with the rheological properties of previous HA fillers [10].
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J Clin Cosmet Dermatol | JCCD
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