Cancer is caused by mutations (changes) in our cells’ genes, or DNA, that allow cells to grow uncontrollably. Knowing the genetic mutations in your melanoma can help you and your doctors decide on the best treatment. If your cancer is high-risk stage 2 or stage 3 (is thicker than 4 mm (millimeters) or involves nearby lymph nodes), your doctor may recommend that your biopsy samples be tested for certain gene mutations. This would help you and your doctor make a more informed treatment plan. Knowing the genetic mutations in your melanoma
Common genetic mutations in melanoma Your doctor may test for these mutations:
BRAF This is the most common mutation in melanoma. About half of people (50%) with common melanoma subtypes have the BRAF mutation in their melanoma. NRAS This mutation happens in about 1 in 5 people (20%) with melanoma.
KIT This mutation is uncommon but is most often seen in melanoma in the mouth or digestive tract, or under fingernails or toenails. GNAQ and GNA11 These mutations are most common in melanoma of the eye.
Not all melanomas need to have genetic testing of biopsy samples. Ask your doctor if this is right for you .
8 Melanoma Patient and Caregiver Guide | Stages 2–3
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