Some treatments target gene mutations Scientists have developed treatments (also called therapies) that target some of these genetic mutations in melanoma. These targeted therapies tend to work better to slow or stop the cancer with fewer side effects than some other cancer treatments. Read more about targeted therapy in the Melanoma Patient and Caregiver Guide for Stages 3–4.
A specific type of testing: Gene expression profile (GEP)
What is GEP? A type of test that analyzes the expression patterns of certain genes within the melanoma cancer cells. This can help predict how aggressive a tumor might be and the chances of it coming back. What might GEP be used for? Some tests combine this genetic information with other factors, like tumor size and patient characteristics, to estimate the chance of melanoma spreading to the lymph nodes or returning in the future. The results could help guide decisions about management, such as whether to have a sentinel lymph node biopsy, see other specialists or increase follow-up care. Who might benefit from GEP? These tests are not currently incorporated into national melanoma guidelines, but may be helpful for people with stages 1–3 melanoma. Future studies will likely address this and provide better guidance on who should get this testing and how it can be used to help people with melanoma.
Be an active partner in your care When you feel ready, learn as much as you’re
comfortable with about your type of melanoma. The more you know, the more you can partner with your cancer care team to decide on the best treatment for you.
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