A one-pot dual C-C bond forming cascade process via Suzuki coupling and intramolecular cyclocondensation: an access to functionalized naphthalenes Pradip Sanjay Waghmare, Chinnabattigalla Sreenivasulu a and Gedu Satyanarayana* a Indian Institute Of Technology Hyderabad, India Herein, we are presenting the development of synthetic strategies to achieve naphthyl ketones in single-step reactions from readily available materials is highly desirable. The domino one-pot synthesis of functionalized naphthyl ketones via intermolecular Suzuki-Miyaura coupling followed by an intramolecular γ-aldol-type condensation with the g -methyl/methylene groups is reported. The present strategy showcased a broad substrate scope and good functional group tolerance and enabled access to a variety of highly substituted naphthalenes starting from the easily accessible starting materials such as α -iodoenone and 2-formylphenylboronic acids as well as 2-formylphenylboronic pinacol esters. Graphical abstract:
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