Of natural products and the chemistry they inspire Alois Fürstner Max-Planck-Institut für Kohlenforschung, Germany
In this lecture I intend to discuss the development of new catalytic transformations and to show their impact on logic and practice of target-oriented synthesis. The focus will be on recent advances in alkyne functionalization with the aid of metal alkylidyne complexes [1] , carbophilic Lewis-acid catalysts [2] , as well as by unorthodox metal- catalyzed addition reactions [3] . These methods opened access to a host of target molecules of different chemical estates with promising biological activities [4-9] . In some cases, our synthesis campaigns led to the revision of the structures and/or bioactivities originally proposed by the isolation teams. References 1. A. Fürstner, J. Am. Chem. Soc . 2021 , 143 , 15538. 2. A. Fürstner, Acc. Chem. Res . 2014 , 47 , 925. 3. A. Fürstner, J. Am. Chem. Soc . 2019 , 141 , 11. 4. Z. Meng, S. M. Spohr, S. Tobegen, C. Farès, A. Fürstner, J. Am. Chem. Soc . 2021 , 143 , 14402. 5. S. N. Hess, X. Mo, C. Wirtz, A. Fürstner, J. Am. Chem. Soc . 2021 , 143 , 2464. 6. G. Späth, A. Fürstner, Angew. Chem. Int. Ed . 2021 , 60 , 7900. 7. Z. Meng, A. Fürstner, J. Am. Chem. Soc . 2019 , 141 , 805. 8. A. G. Dalling, G. Späth, A. Fürstner, Angew. Chem. Int. Ed . 2022 , 61 , e202209651. 9. R. J. Zachmann, K. Yahata, M. Holzheimer, M. Jarret, C. Wirtz, A. Fürstner, J. Am. Chem. Soc . 2023 , 145 , 2584.
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