From sulfonium salts to samarium catalysis: new radical chemistry for synthesis David J. Procter University of Manchester, UK Part I – Our approach to the development of transition metal-free cross-coupling processes is based on the proposal that sulfur can replace metals in activating substrates and generating reactive intermediates for exploitation in carbon–carbon bond-formation. In particular, we will describe the exploitation of in situ generated aryl sulfonium salts in photocatalytic 1 and photochemical 2 coupling processes involving aryl radicals.
Part II – Samarium(II) iodide is one of the most widely-used single electron transfer reductants in chemistry. We will highlight the reagent’s ability to unlock key steps in natural product synthesis 3 and will describe our recent studies on catalysis with SmI2 . 4,5,6
References 1. M. H. Aukland, M. Šiaučiulis,A. West, G. J. P. Perry, D. J. Procter, Nat. Catal. 2020, 3 , 163 2. A. Dewanji, L. van Dalsen, J. A. Rossi-Ashton, E. Gasson, G. E. M. Crisenza, D. J. Procter, Nat. Chem. 2023, 15 , 43 3. Á. Peter, G. E. M. Crisenza, D. J. Procter, J. Am. Chem. Soc. 2022, 144 , 7457 4. H-M. Huang, J. J. W. McDouall, D. J. Procter, Nat.Catal. 2019, 2 , 211 5. S. Agasti, N. A. Beattie, J. J. W. McDouall, D. J. Procter, J. Am. Chem. Soc. 2021, 143 , 3655 6. S. Agasti, F. Beltran, E. Pye, N. Kaltsoyannis, G. E. M. Crisenza, D. J. Procter, Nat. Chem. 2023, 15 , 535
I02
© The Author(s), 2023
Made with FlippingBook Learn more on our blog