New directions in drug discovery: expanding exploration of chemical space Emma Parmee Janssen Pharmaceutical Companies of Johnson & Johnson, USA This presentation will highlight several strategic elements aimed at expanding our exploration of chemical space in Drug Discovery. Firstly, the talk will describe efforts to explore novel modalities to drug the most difficult targets in our industry. Recent breakthroughs in chemistry capabilities and their role in rapidly expanding chemical space to accelerate the molecular optimization “design cycle” will be also described. The latter topic also illustrates the importance of a continued focus on the crucial role synthetic chemistry plays in enabling and inspiring design in Drug Discovery.
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