Core editing of taxmen diterpenes - a generalised total synthesis Tanja Gaich, Dr. Lu Pan, Dr. Fabian Schneider, Dr. Konstantin Samarin University Konstanz, Germany A generalised total synthesis of cyclotaxanes is presented. The approach involves a fragmentationstrategy starting from a precursor of the canataxpropellane total synthesis by our group in 2020 [1] . The pitfalls encountered in this synthetic endeavour will be presented and thus delineate the final successful route. Special focus will be played on conformational effects which strongly influenced potential side reactions in specific cases, and thus the understanding of these effects is crucial for the overall success in our total synthesis of different cyclotaxanes [2] . References 1. Schneider F, Samarin K, Zanella S, Gaich T. (2020) Total synthesis of complex taxane diterpene canataxpropellane Science , 367 (6478), 676–681. DOI: 10.1126/science.aay9173 2. Schneider F, Pan L, Ottenbruch M, List T, Gaich T. (2021) The Chemistry of non-classical taxane diterpenes. Acc. Chem. Res. 54 (10), 2347–2360. https://doi.org/10.1021/acs.accounts.0c00873
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© The Author(s), 2023
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