Controlled ancillary ligand exchange generating artificial palladium (II) metalloproteins and their related catalytic activities investigations Xinyue Gao, Isabeau Lüddecke, Eva Klemencic, Dr Richard Brewster, Dr Amanda G. Jarvis* University of Edinburgh, UK Artificial metalloproteins have garnered significant attention as highly effective catalysts for various chemical reactions [1] . This poster presents our recent work on developing artificial palladium metalloprotein catalysts for organic synthesis. Our strategy is inspired by published controlled-ancillary ligand exchange work [2] and involves incorporating palladium ions into the protein scaffold one-to-one, allowing for precise control over the coordination geometry and ligand environment of the palladium centre. We have successfully designed and synthesised several palladium metalloproteins, one of which has been confirmed by the X-ray crystal structure. We are currently investigating their catalytic activity and selectivity in a range of organic transformations, including cross- coupling reactions [3] and asymmetric catalysed hydroamination [4] . Additionally, we are actively working to optimise the protein structure and metal binding properties further to enhance the catalytic performance of these artificial metalloproteins. Our research will present a promising approach to developing a new generation of efficient and selective palladium catalysts for organic synthesis. References 1. J. C. Lewis, ACS Catal. 2013 , 3 , 2954-2975. 2. G. S. Biggs, O. J. Klein, S. L. Maslen, J. M. Skehel, T. J. Rutherford, S. M. V. Freund, F. Hollfelder, S. R. Boss, P. D. Barker, Angew. Chem., Int. Ed. 2021 , 60 , 10919-10927. 3. A. Chatterjee, H. Mallin, J. Klehr, J. Vallapurackal, A. D. Finke, L. Vera, M. Marsh, T. R. Ward, Chem. Sci. 2016 , 7 , 673-677. 4. M. Pal, D. Musib, M. Pal, G. Rana, G. Bag, S. Dutta, M. Roy, Org.Biomol. Chem. 2021 , 19 , 5072-5076.
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